Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



VEGFR3 signaling in lymphatic endothelium

Related component ;click for the further info from NCBI
PI-3KVEGFR3VEGFC-DSHCGRB2
SOS1ERK1-2PKCERK1-2-activeMKK4
VEGFDCollagenalpha2beta1 IntegrinCREB1
p38alpha-beta-activep90S6KFibronectinalpha5alpha4
Crkalpha1CRKAKT1

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
207458 PI-3K   modification input plasma membrane 16076871  11532940    
207461 ERK1-2   modification input 11532940    
207483 MKK4   cell survival agent cytoplasm active 16076871    
207480 VEGFR3  VEGFC-D   vasculogenesis agent plasma membrane active 16633338    
207476 VEGFR3  VEGFD  Collagen  alpha2  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207457 VEGFR3  VEGFC-D   lymphangiogenesis agent plasma membrane active 16633338    
207463 CREB1   modification input 11335727  11532940    
207464 VEGFR3   modification input plasma membrane 11553610    
207479 VEGFR3  VEGFD  Fibronectin  alpha5  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207455 SHC  GRB2  SOS1   modification input 9927207  7675451  8662748    
207474 VEGFR3  VEGFD   modification input plasma membrane active 11553610    
207471 VEGFR3  Fibronectin  alpha5  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207472 VEGFR3  VEGFD   modification input plasma membrane active 11553610    
207462 p90S6K   modification input 11335727  11532940    
207478 VEGFR3  VEGFD  Fibronectin  alpha4  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207482 MKK4   modification input cytoplasm 16076871    
207465 VEGFR3   modification input plasma membrane 11553610    
207481 VEGFR3  VEGFC-D   modification input plasma membrane active 16076871    
207473 VEGFR3  VEGFD   modification input plasma membrane active 11553610    
207475 VEGFR3  VEGFD   modification input plasma membrane active 11553610    
207470 VEGFR3  Fibronectin  alpha4  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207468 VEGFR3  Collagen  alpha2  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207484 ERK1-2   modification input 16076871    
207456 SHC  GRB2  SOS1   DNA mediated transformation inhibitor plasma membrane active 9927207  8662748    
207459 AKT1   modification input plasma membrane 11532940    
207467 VEGFR3   modification input plasma membrane 11553610    
207466 VEGFR3   modification input plasma membrane 11553610    
205705 ERK1-2-active   cell proliferation agent active 15466214  12743104  16076871    
207469 VEGFR3  Collagen  alpha1  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207477 VEGFR3  VEGFD  Collagen  alpha1  beta1 Integrin   cell migration agent plasma membrane active 11553610    
207460 PKC   modification input 11532940    
207454 VEGFR3   modification input plasma membrane 8617204  9927207  16076871  10449752  9012504  9247316  9435229  16633338  12881528