Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



EPHA2 forward signaling

Related component ;click for the further info from NCBI
Ephrin A1EPHA2SrcRhoAGTP
p52 SHCFAK1Rac1PAK1CBL
PI-3-4-5-P3SHIP2PI-3-4-P2RAC1GDP
VAV2-VAV3LMW-PTPTiam1PI-3KPI3K
p130 CasGRB2p190RHOGAPPI-4-5-P2S1P

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
207380 Ephrin A1  EPHA2   modification input integral to membrane active 18198190    
204927 RhoA  GTP   cell-cell adhesion inhibitor plasma membrane active 11870224  18198190    
207373 Ephrin A1  EPHA2   modification input integral to membrane active 12400011    
207363 Ephrin A1  EPHA2   modification input integral to membrane 18387945    
207385 FAK1   modification input cytoplasm inactive 12134157    
207372 Ephrin A1  EPHA2   endocytosis input integral to membrane active 17135240    
207384 FAK1   cell adhesion mediated by integrin inhibitor cytoplasm inactive 10655584    
207393 PAK1   substrate adhesion-dependent cell spreading inhibitor cytoplasm inactive 12615978    
207394 Ephrin A1  EPHA2   proteasomal ubiquitin-dependent protein catabolic process input integral to membrane active 12496371    
207371 PI-3-4-5-P3   modification input plasma membrane 17135240    
207368 RAC1  GDP   modification input inactive 17135240  15054110    
207364 Ephrin A1  EPHA2   modification input integral to membrane active 18387945  16782872    
207378 Ephrin A1  EPHA2   modification input integral to membrane active 18198190    
207388 Ephrin A1  EPHA2   modification input integral to membrane active 14988728    
207366 Ephrin A1  EPHA2   modification input integral to membrane active 7982920  18387945    
207389 RAC1  GDP   modification input inactive 14988728    
207370 Ephrin A1  EPHA2  VAV2-VAV3   angiogenesis agent integral to membrane active 15054110  18387945  16782872    
207365 RAC1  GDP   modification input inactive 18387945  16782872    
207387 RhoA  GTP   substrate adhesion-dependent cell spreading agent plasma membrane active 12134157    
207375 Ephrin A1  EPHA2  p52 SHC  GRB2   MAPKKK cascade agent integral to membrane active 12400011    
207386 p130 Cas   modification input 12134157    
207362 Ephrin A1   modification input integral to membrane 8755474    
207377 RhoA  GTP   modification input plasma membrane active 18198190    
207369 Rac1  GTP   endothelial cell migration agent active 15054110    
207383 FAK1   modification input focal adhesion active 10655584    
207374 Ephrin A1  EPHA2  p52 SHC   modification input integral to membrane active 12400011    
207381 Ephrin A1  EPHA2  Src   cell-cell adhesion inhibitor integral to membrane active 18198190    
207379 p190RHOGAP   modification input active 18198190    
207392 PAK1   modification input cytoplasm inactive 12615978    
207367 PI-4-5-P2   modification input plasma membrane 7982920    
207376 RhoA  GDP   modification input plasma membrane inactive 18198190    
207391 Rac1  GTP   modification input active 12615978    
205228 Rac1  GTP   neuron projection morphogenesis agent active 14988728  16481401  12879077