Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



Class I PI3K signaling events mediated by Akt

Related component ;click for the further info from NCBI
AKT1PDK1SrcHsp90ASK1
AKT2PI-3-4-5-P3Pro-Caspase 9p27Kip1GLUT4
AS160FOXO1-3a-4FOXO1-3a-4-inactivemTORRHEB
GDPRaptorGBLPRAS40TSC1
TSC2GTPRAF1GSK3-inactive14-3-3 family
p21CIP1BCL-XLAKT3DNA-PKcsIKK alpha
BADYWHAZKPNA1PKAGSK3
mTORC2

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
206808 AKT1   modification input plasma membrane 9094314  17407381  18024423  9637919    
206830 AKT1  ASK1   JNK cascade inhibitor 11154276    
206814 AKT2   modification input 9512493    
206819 Pro-Caspase 9   cell survival agent inactive 9812896    
206842 p27Kip1   modification input 12244302  12244301  12244303    
206827 GLUT4   translocation input cytoplasm 16213228  12637568    
206821 FOXO1-3a-4   modification input nucleus 10102273    
206809 mTOR  RHEB  GDP  Raptor  GBL  PRAS40   modification input inactive 16962653  12869586  17386266  12820960  12172553    
206837 AKT1   modification input plasma membrane active 10576741    
206832 GSK3-inactive   G1/S transition of mitotic cell cycle agent inactive   
206823 FOXO1-3a-4  14-3-3 family   cell survival agent cytoplasm inactive 10102273  11777915    
206840 p21CIP1   translocation input nucleus 11231573    
206839 AKT2   modification input active 11231573  16982699    
206833 AKT1   pathway input plasma membrane active   
206826 AS160   modification input active 12637568    
206828 GLUT4   glucose import agent plasma membrane active 16213228    
206844 p27Kip1  14-3-3 family   negative regulation of cell cycle inhibitor cytoplasm inactive 12244302  12244301  12244303    
206732 BCL-XL   cell survival agent 10949026    
206841 p21CIP1   negative regulation of cell cycle inhibitor cytoplasm inactive 16982699    
206807 AKT1   translocation input cytoplasm 17407381    
206824 FOXO1-3a-4  14-3-3 family   negative regulation of cell cycle inhibitor cytoplasm inactive 10783894    
206815 AKT3   modification input 9512493    
206825 AKT1   modification input plasma membrane active 15262962    
206812 TSC2   proteasomal ubiquitin-dependent protein catabolic process input inactive 12172553    
206822 FOXO1-3a-4-inactive   modification input nucleus inactive 11864996  10217147  10102273  10358075    
206816 IKK alpha   modification input cytoplasm 10485710    
206730 BAD  BCL-XL   modification input mitochondria 10949026    
206843 p27Kip1   modification input 15057270  12244302  12244301  12244303    
206731 BAD  BCL-XL  YWHAZ   modification input mitochondria 10949026    
206729 BAD  BCL-XL   modification input mitochondria 9346240  9381178    
206817 IKK alpha   pathway input cytoplasm   
206829 AKT1   modification input plasma membrane active 11154276    
206818 Pro-Caspase 9   modification input 9812896    
206831 GSK3   modification input 8524413    
206838 AKT1  RAF1   MAPKKK cascade inhibitor active 10576741    
206813 mTOR  RHEB  GTP  Raptor  GBL   pathway input active   
203262 AKT1   modification input plasma membrane active 12682230  16919458  11136732  18596232  16962653  12750173  10570282  15718470