Related Signaling interaction pathway:

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Signaling events mediated by VEGFR1 and VEGFR2

Related component ;click for the further info from NCBI
SHCGrb2SOS1VEGFR2 homodimerVEGFA homodimer
GRB2PDK1PI-3-4-5-P3p38 betaGRB10
Hsp27MAPKA C-alphaP2-3TsAdFESFAK1
PYK2eNOSHsp90CaMCa2+
AKT1PKA C-alphaIP3VinculinPLCgamma1
SHP1VEGFA165NRP1alphaVbeta3 Integrin
CDC42PI-3KGab1SrcShb
PI3KGAB1Caveolin-1VEGFR1VEGFR1 homodimer
VEGFR2Fyn3 heterodimerVEGFC homodimerERK1-2-active
S1P1DAG2 heterodimerNRP2PAS
HIF1AARNTVHLMKK3MLK
IQGAP1RacVEGFA145ERK1-2PKC alpha
Sck (SHC2)SckNEDD4YesL-arginine
NADPHO2L-citrullineNONADP
Frs2PaxillinRAC1PKC beta2PI-4-5-P2
RhoAROCK1VEGFRhoIntegrin Complex
NckPakVEGFBGTPHRAS
GDPVE-Cadherinbeta cateninCadherinSHP2
SHBHIF2AFRS2NCK1VEGFR3

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
206434 SHC  Grb2  SOS1   modification input 9405464    
200957 PDK1   translocation input cytoplasm 9637919    
206433 p38 beta   platelet activating factor biosynthetic process agent active 11704645    
206479 VEGFR2 homodimer  VEGFA homodimer   transcription agent plasma membrane active 11494124    
206504 Hsp27   modification input 14724572  10744763  10207622    
206487 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 15962004  10692392    
206448 FES   modification input 12821150    
204327 FAK1   modification input cytoplasm 16760434  9182576    
206425 eNOS  Hsp90   translocation input plasma membrane 10908731  10376602  12171920  11978735  10376603  16839566    
200251 Ca2+   translocation input calcium store 3919143  15879121  17675482  9820480  19158393  9722546  12598525  17242406  9398617  12482967  9115251  9435453  8125934    
206473 FAK1   modification input cytoplasm active1   
206414 PLCgamma1   modification input cytoplasm 12598525  9398617  11387210    
206441 VEGFR2 homodimer  VEGFA homodimer  SHP1   modification input plasma membrane active 16337972    
206463 VEGFA165  NRP1   modification input 16763549  11948691    
204325 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 16760434    
206502 p38 beta   modification input 14724572  10744763  10207622    
206408 PI-3K   modification input cytoplasm 15962004  16787925    
206000 eNOS  Caveolin-1   modification input plasma membrane 11425855    
206396 VEGFR1   modification input plasma membrane   
206397 VEGFR2   modification input plasma membrane   
206471 FAK1  Vinculin   cell migration agent active 15247219    
206500 VEGFR2 homodimer  VEGFA homodimer   transcription agent plasma membrane active 11756651    
206446 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 12509223  16966330    
206490 VEGFR2  3 heterodimer   modification input plasma membrane 16633338    
206413 AKT1   modification input cytoplasm active 16787925    
206004 ERK1-2-active   platelet activating factor biosynthetic process agent active 12598525  11704645    
202750 VEGFR2 homodimer  VEGFA homodimer   transcription agent plasma membrane active 12963813    
206423 Ca2+   modification input cytoplasm   
206445 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 12509223    
206442 VEGFR2 homodimer  VEGFA homodimer  SHP1  eNOS   endothelial cell proliferation agent plasma membrane active 16337972    
206398 VEGFR1   modification input plasma membrane   
206503 MAPKA C-alphaP2-3   modification input 14724572  10744763  10207622    
206457 VEGFA165   modification input 11986311    
206499 PAS   transcription agent nucleus   
206505 Hsp27   stress fiber formation agent active 14724572  10744763  10207622    
206432 p38 beta   modification input 11704645    
206404 VEGFR1 homodimer   subnet input plasma membrane   
206403 VEGFR1  2 heterodimer   modification input plasma membrane   
206431 MKK3   modification input 11704645    
206493 VEGFR2 homodimer  VEGFA homodimer  IQGAP1  Rac   oxygen and reactive oxygen species metabolic process agent plasma membrane active 15217908    
206462 NRP2   modification input 10748121    
206481 VEGFR2 homodimer  VEGFA homodimer  GRB10   MAPKKK cascade agent plasma membrane active 11494124    
206003 ERK1-2   modification input 12598525  11704645    
206477 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 9790910  16633338  12214271  10749680    
206482 VEGFR2 homodimer  VEGFA homodimer  GRB10   modification input plasma membrane active 15060076    
206447 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 12509223    
206406 PI-3K   modification input cytoplasm 11312102  9600074  8903320    
202524 L-arginine   modification input cytoplasm 10908731  10376602  11978735  12171920  17466390  15162796  10376603    
206452 VEGFR2 homodimer  VEGFA homodimer  Frs2   modification input plasma membrane active 12154000    
206468 FAK1  Paxillin   cell migration agent active 16760434  9182576    
205997 PKC alpha   endothelial cell proliferation agent active 12598525  11704645    
206456 VEGFA165   modification input 11986311    
206491 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 15217908    
205998 PKC beta2   endothelial cell proliferation agent active 12598525  11704645    
205993 PI-4-5-P2   modification input plasma membrane 12598525  11312102  9398617    
206465 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 15247219  16760434    
206453 VEGFR2 homodimer  VEGFA homodimer  Frs2   modification input plasma membrane active 16966330  12154000    
206455 VEGFB   modification input 11333271  10409677    
206430 MLK   modification input 11704645    
206451 VEGFR2 homodimer  Frs2   modification input plasma membrane 12154000    
206435 GTP   modification input 9405464    
206488 VEGFR2 homodimer  VEGFA homodimer  TsAd   actin cytoskeleton reorganization agent plasma membrane active 16835467  16633338    
206494 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 16763158    
206443 SHP2   modification input cytoplasm 9600074    
206449 SHB   modification input 16633338  15026417    
206492 VEGFR2 homodimer  VEGFA homodimer  IQGAP1  Rac   cell migration agent plasma membrane active 15217908    
206464 VEGFA165  NRP2   modification input 16763549  11948691    
206407 Gab1   modification input cytoplasm 16787925    
206467 FAK1   modification input cytoplasm active 16760434  9182576    
200607 PI-4-5-P2   modification input plasma membrane 11438544    
206501 CDC42   modification input cytoplasm 14724572    
206475 PYK2   modification input cytoplasm 16760434    
200510 HRAS  GTP   MAPKKK cascade agent active 9405464  12087092  7809106    
206498 HIF2A   transcription agent nucleus 10361126    
206450 VEGFR2 homodimer   modification input plasma membrane 12154000    
206006 AKT1   endothelial cell proliferation agent cytoplasm active 9804796    
206466 FAK1   modification input cytoplasm 16760434  9182576    
206440 SHP1   modification input 16337972    
205996 PKC beta2   modification input 12598525  11704645    
206437 NCK1   modification input cytoplasm 9600074    
206402 VEGFR2 homodimer   modification input plasma membrane 15962004    
206472 FAK1   modification input cytoplasm   
205995 PKC alpha   modification input 12598525  11704645  9398617    
206480 GRB10   modification input plasma membrane 11494124    
206428 ERK1-2   modification input 12598525  11704645    
206495 VEGFR2 homodimer  VEGFA homodimer  IQGAP1  Cadherin  beta catenin   cell migration agent plasma membrane active 16763158    
206470 FAK1   modification input cytoplasm active 15247219    
206489 VEGFR3   modification input transmembrane 12881528    
205989 PI3K  GAB1   translocation input cytoplasm active 16787925    
206483 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 15060076