Related Signaling interaction pathway:

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Caspase cascade in apoptosis

Related component ;click for the further info from NCBI
PARP1Caspase 7 (cleaved)PARP1 (cleaved)Pro-Caspase 7Caspase 2 (cleaved)
Mammalian IAPsCaspase 3 (cleaved)Granzyme BPerforin 1Cytokeratin 18
Caspase 6 (cleaved)Cytokeratin 18 fragment 1Cytokeratin 18 fragment 2Pro-Caspase 10Caspase 10 (cleaved)
NuMA (cleaved by caspase 3)Vimentin fragment 1Pro-Caspase 1Caspase 4 (cleaved)crmA
Caspase 1 (cleaved)Caspase 8Caspase 8 (cleaved)Pro-Caspase 3BID
p15 BIDCytochrome CBAXGelsolinFAK1
FAK1 fragment 3FAK1 fragment 4NuMANuMA (cleaved by caspase 6)SLK fragment
ActinActin fragment 1Actin fragment 2LaminsLamins (cleaved)
alpha Fodrinalpha Fodrin (cleaved)Pro-Caspase 2TNF-alphaTNFR1A
TRADDMADDcIAP2RIP1TRAF2
RAIDDPIDDbeta APPbeta APP fragmentLIMK1
LIMK1 fragmentSATB1SATB1 (cleaved)Pro-Caspase 6Vimentin fragment 3
MEKK1 fragment 2DNA TOP1DNA TOP1 fragment 4DNA TOP1 fragment 5DNA TOP1 fragment 6
APAF-1Pro-Caspase 9DIABLOCaspase 9AP-2 alpha
AP-2 alpha (cleaved)DNA TOP1 fragment 1DNA TOP1 fragment 2DNA TOP1 fragment 3Vimentin
Vimentin fragment 4MEKK1MEKK1 fragment 1ICADCAD
ICAD (cleaved)Gas2Gas2 (cleaved)Cofilin-2Rho GDI beta
Rho GDI beta fragmentVimentin fragment 2Gelsolin (cleaved)Ca2+SLK
SREBF1SREBF1 (cleaved)FAK1 fragment 1FAK1 fragment 2Activated DNA
NADAP-24BCL2AP-24 (cleaved)

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
205856 PARP1   modification input active1 10497198    
205866 Pro-Caspase 7   modification input   
205855 PARP1   modification input 7774019    
205854 Granzyme B   translocation input extracellular region 10567584    
205886 Cytokeratin 18   modification input 9298992    
205839 Pro-Caspase 10   modification input   
205893 NuMA (cleaved by caspase 3)   DNA fragmentation during apoptosis agent   
205836 Pro-Caspase 7   modification input   
205906 Vimentin fragment 1   apoptosis agent   
205842 Pro-Caspase 1   modification input   
205852 Caspase 8   modification input   
205841 Pro-Caspase 3   modification input   
205857 PARP1 (cleaved)   DNA repair inhibitor inactive 10497198    
205870 BID   modification input cytoplasm 12419244    
205860 Cytochrome C   modification input mitochondria 10809769    
205888 FAK1   modification input   
205890 NuMA   modification input 9463409    
205882 SLK fragment   stress fiber formation agent active   
205871 Actin   modification input 9070648    
205851 Lamins   modification input 11953316    
205858 Lamins (cleaved)   positive regulation of apoptosis agent 11953316    
202595 alpha Fodrin   modification input 8940132  9624143    
205863 Pro-Caspase 2   modification input   
205892 NuMA   modification input   
205895 beta APP   modification input   
205883 LIMK1   modification input 15189451    
205873 alpha Fodrin (cleaved)   apoptotic nuclear changes agent   
205899 SATB1   modification input 11463840    
205865 Pro-Caspase 6   modification input   
205908 Vimentin fragment 3   apoptosis agent   
205912 MEKK1 fragment 2   JNK cascade inhibitor   
205867 BID   modification input cytoplasm 11085743    
205898 DNA TOP1   modification input   
205859 Cytochrome C   modification input mitochondria   
205840 Pro-Caspase 3   modification input   
205850 Lamins   modification input 11953316    
205861 APAF-1  Pro-Caspase 9   modification input   
205901 AP-2 alpha   modification input 11438643    
205869 p15 BID   modification input mitochondria   
205897 DNA TOP1   modification input 9933635    
205862 Pro-Caspase 3   modification input   
205894 beta APP   modification input 10409650    
205904 Vimentin   modification input   
205910 MEKK1   modification input 9528810    
205848 ICAD  CAD   modification input 9422506  9422513    
205891 NuMA (cleaved by caspase 6)   nuclear fragmentation during apoptosis agent   
205874 Gas2   modification input 10564664    
205884 Cofilin-2   modification input   
205909 Vimentin fragment 4   apoptosis agent   
202599 Rho GDI beta   modification input 8626669    
205903 Vimentin   modification input 11423904    
205911 MEKK1 fragment 1   JNK cascade inhibitor   
205879 Actin   modification input   
205864 Pro-Caspase 3   modification input   
205885 Cofilin-2   actin filament polymerization inhibitor inactive   
205838 Pro-Caspase 3   modification input 8700869    
205907 Vimentin fragment 2   apoptosis agent   
205880 SLK   modification input 10611247    
205837 Pro-Caspase 7   modification input   
205905 Vimentin   modification input   
205878 Gelsolin   modification input 9323209    
205845 SREBF1   modification input 8605870    
205843 Pro-Caspase 3   modification input   
205889 FAK1   modification input   
205877 PARP1   modification input   
205849 CAD   DNA fragmentation during apoptosis agent cytoplasm active 9422506  9422513    
205844 Pro-Caspase 6   modification input   
205876 Mammalian IAPs   modification input 11803376    
205846 AP-24   modification input 9588194  9850096    
205887 FAK1   modification input 9642276    
205902 AP-2 alpha (cleaved)   negative regulation of DNA binding agent   
205896 beta APP fragment   neuron apoptosis agent   
205881 SLK fragment   apoptosis agent active