Related Signaling interaction pathway:

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Signaling events mediated by the Hedgehog family

Related component ;click for the further info from NCBI
SHH NpCholesterolCDOPTCH1SIL
SMObeta Arrestin2Dnchc2MegalinLRPAP1
HhipDHH NPTCH2IHH NGLI3R
PTHrPAKT1PI-3KTGF-beta2Vitamin D3
GRK2GLI2GLI2ABOCGAS1
Disp1SHHHHATSHH C

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
205685 SHH Np  Cholesterol   modification input extracellular region 16647304  16647303    
205676 PTCH1   translocation input integral to membrane inactive 12123571    
205682 SIL   modification input 11668681    
205649 SHH Np  Cholesterol  PTCH1   receptor-mediated endocytosis agent integral to membrane 11027307    
205688 SMO  beta Arrestin2   subnet input clathrin coat of coated pit active   
205673 SMO  beta Arrestin2   translocation input clathrin coat of coated pit active 16136078  16229832    
205692 SHH Np  Cholesterol   subnet input extracellular region   
205683 SHH Np  Cholesterol   modification input extracellular region 11964399    
205658 SMO   determination of left/right symmetry agent integral to membrane active 11517919    
205669 Hhip   pancreas development agent integral to membrane 12917290    
205654 DHH N   modification input extracellular region 9811851    
205679 IHH N  PTCH1   transcription agent integral to membrane 10465785  16284117    
205689 AKT1   subnet input cytoplasm active   
205670 AKT1   modification input cytoplasm 16537363    
205653 DHH N   modification input extracellular region 9811851    
205677 IHH N  PTCH1   transcription agent integral to membrane 11934857    
205661 SMO   heart development agent integral to membrane active 11517919    
205648 SHH Np  Cholesterol   modification input extracellular region 9811851  11027307  8906794    
205680 IHH N  PTCH1   transcription agent integral to membrane 16284117    
205667 IHH N   modification input extracellular region 10050855    
205656 SMO  Vitamin D3   modification input integral to membrane inactive 16895439    
205662 SMO   modification input integral to membrane active 15618519    
205666 DHH N   modification input extracellular region 10050855    
205687 GLI2   modification input cytoplasm 16647304    
205663 SMO   modification input integral to membrane active 12123571  15618519    
205660 SMO   heart looping agent integral to membrane active 11517919    
205678 TGF-beta2   transcription agent 11934857    
205684 SHH Np  Cholesterol  Megalin   receptor-mediated endocytosis agent integral to membrane active 11964399    
205668 SHH Np  Cholesterol  Hhip   mesenchymal cell differentiation inhibitor integral to membrane inactive 15019948    
205657 SMO  Vitamin D3   modification input integral to membrane inactive 11517919    
205651 IHH N   modification input extracellular region 9811851    
205690 SMO   subnet input nonmotile primary cilium active   
205674 SHH Np  Cholesterol  PTCH1   modification input integral to membrane 12123571    
205686 SHH Np  Cholesterol   modification input extracellular region 16647304    
205672 SHH Np  Cholesterol  GAS1   dorsoventral neural tube patterning inhibitor integral to membrane inactive 11572986    
205647 SHH Np  Cholesterol   translocation input cytoplasm 12421714  12372301    
205675 PTCH1   catabolic process agent late endosome inactive 12123571    
205659 SMO   somite specification agent integral to membrane active 11517919    
205665 SHH Np  Cholesterol   modification input extracellular region 10050855    
205646 SHH   modification input cytoplasm 9593755  11486055  7891723  8824192    
205691 SMO   subnet input integral to membrane active   
205652 IHH N   modification input extracellular region 9811851    
205664 SMO  beta Arrestin2   receptor-mediated endocytosis agent clathrin coat of coated pit active 15618519    
205681 PTHrP   skeletal system development agent 10465785    
205655 SMO   modification input integral to membrane 10984056  16895439  12192414    
205650 SHH Np  Cholesterol   modification input extracellular region 9811851    
205671 SHH Np  Cholesterol   modification input integral to membrane 11572986