Related Signaling interaction pathway:

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IL6-mediated signaling events

Related component ;click for the further info from NCBI
STAT1PIAS1IL6IL6RAgp130 (dimer)
JAK1LMO4STAT3 (dimer)FOXO1GRB2
SOS1GAB familySHP2A2MHCK
STAT3 (dimer )IRF1STAT3nPKC-deltaSOCS3
CEBPBHSP90B1p38alpha-betaMKK6p38alpha-beta-active
PIAS3MITFJunBCRPAP1
TIMP1LBPMCL1FGGAKT1
PI3KMYCMKK4Rac1GTP
PTPECJAK2TYK2VAV1RANKL
BCL-XLRAC1GDPCEBPDPI-3K
Hck

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
205057 STAT1   modification input cytoplasm active 9724754    
205077 STAT3 (dimer)  FOXO1   transcription agent nucleus active 7678052  9794795  12456685    
205044 GRB2  SOS1  GAB family   modification input 15010462    
205071 STAT3 (dimer )   transcription agent nucleus active 7523403    
205034 STAT3   modification input 9880505  8662591  8272872  15677447  12361954  12754507  10446219  8626374  7537214  12754505  7678052  12754506  8164674  8140422  11335711    
205081 STAT3 (dimer )   cell cycle arrest agent nucleus active 8670868    
205067 STAT3 (dimer )   transcription agent nucleus active   
205049 p38alpha-beta   modification input 11727828    
205056 STAT3 (dimer )   modification input nucleus active 15572665  9388184    
205065 STAT3 (dimer )   transcription agent nucleus active 7898939  8537375    
205041 SHP2   modification input 9794795  12754506    
205062 STAT3 (dimer )   transcription agent nucleus active 8621622    
205064 STAT3 (dimer )   transcription agent nucleus active 8559663    
205054 AP1   modification input nucleus   
205063 STAT3 (dimer )   transcription agent nucleus active 8668165    
205053 MCL1   cell survival agent 12445202    
205047 IL6  IL6RA  gp130 (dimer)  JAK1  JAK1  LMO4   modification input integral to membrane active 10777583    
205050 p38alpha-beta-active   transcription agent active 11727828    
205061 STAT3 (dimer )   transcription agent nucleus active 7678052    
205051 AKT1   modification input 12445202    
205078 STAT3 (dimer )   transcription agent nucleus active 9874564    
205074 FOXO1   modification input nucleus active 12456685    
205039 MKK4   modification input cytoplasm 10727406    
205052 AKT1   transcription agent active 12445202    
205046 GRB2  SOS1  GAB family  SHP2  PI3K   MAPKKK cascade agent active 9632795    
205029 IL6  IL6RA   modification input integral to membrane 7875298  11251120  1662392  15677447  9590172  16254248  9295319  2261637  10605021  10859312  8083235  8272872  9973404  16774741  15722452  11120832  7537214  2788034  11468294  8467812  12829785  8511589    
205030 IL6  IL6RA   modification input integral to membrane 2261637  8272873  2788034  8272872  15677447  12829785  8134389    
205032 IL6  IL6RA   modification input integral to membrane 2261637  8272873  2788034  8272872  12829785  10859312    
205080 STAT3 (dimer )   macrophage differentiation agent nucleus active 8670868    
205076 STAT3 (dimer )   modification input nucleus active 12456685    
205037 VAV1   modification input cytoplasm 10727406    
205070 RANKL   bone resorption agent 10383440    
205068 STAT3 (dimer )   transcription agent nucleus active 10023775    
205079 STAT3 (dimer )   cell survival agent nucleus active 10023775    
205042 SHP2   modification input active 15010462  10409724    
205048 MKK6   modification input 11727828    
205028 IL6   modification input extracellular region 3136546  2788034  12829785    
205038 RAC1  GDP   modification input inactive 10727406  11335711    
205066 STAT3 (dimer )   transcription agent nucleus active 9163525    
205040 nPKC-delta   modification input 11335711    
205043 GRB2  SOS1  GAB family  SHP2   MAPKKK cascade agent active 15010462  10409724    
205075 FOXO1   translocation input nucleus 12456685    
205033 STAT1   modification input 7537214  8662591  12754505  8272872  12754506  8164674    
205069 STAT3 (dimer )   transcription agent nucleus active 10383440    
205036 STAT3   translocation input cytoplasm active 7537214  9590172  15935617    
205045 GRB2  SOS1  GAB family  SHP2   modification input active 9632795    
205055 IL6  IL6RA  gp130 (dimer)  JAK1  JAK1  LMO4   modification input integral to membrane active 11689697