Related Signaling interaction pathway:

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ErbB2/ErbB3 signaling events

Related component ;click for the further info from NCBI
PKAErbB2ErbB3neuregulin 1 betaJNK1
MEK1-2RAF1MEK1-2-activeSchwannominJUN
RAS familyGTPCa2+SHCGRB2
SOS1SHP2PI3K Class IA familyERK1-2-activeBAD
STAT3 (dimer)RAC1-CDC42GDPDOCK7FOS
NFATc4mTORAKT1USP8Calcineurin A beta
STAT3PI-3-4-5-P3CHRNENRDP1CHRNA1
PI-4-5-P2cAMPJNK family-activeJAK2Src
JNK familyneuregulin 2ERK1-2

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
204825 PKA   modification input 17998937    
204840 JNK1   modification input 10493750    
204824 ErbB2  ErbB3  neuregulin 1 beta   mammary gland morphogenesis agent integral to membrane 19019207    
204809 MEK1-2   modification input 18799465    
204827 Schwannomin   cell proliferation agent inactive 17998937    
204826 Schwannomin   modification input active 17998937    
204831 MEK1-2   modification input 18799465    
204823 ErbB2  ErbB3  neuregulin 1 beta   heart morphogenesis agent integral to membrane 11984589  12072561  9362461  10399934    
203026 JUN   modification input nucleus 10493750  9407028    
204829 ErbB2  ErbB3  neuregulin 1 beta   modification input integral to membrane 18799465    
204808 RAF1   modification input 10531446    
204842 Ca2+   modification input calcium store 19179536    
204806 ErbB2  ErbB3  neuregulin 1 beta  SHC   modification input integral to membrane 9694850  10531446  9710588  11173924    
204821 ErbB2  ErbB3  neuregulin 1 beta   nervous system development agent integral to membrane 10704452  9338783  16481445  10399934  9637684    
204830 PI3K Class IA family   modification input 18799465    
204811 ERK1-2-active   cell proliferation agent cytoplasm active 18799465  10704452  16481445  12651161  7877996    
204799 BAD   apoptosis inhibitor cytoplasm inactive 11312610    
204835 STAT3 (dimer)   translocation input cytoplasm active 11940572    
204837 RAC1-CDC42  GDP   modification input inactive 18426980    
204820 ErbB2  ErbB3  neuregulin 1 beta   ubiquitin-dependent protein catabolic process input integral to membrane 17210635  12411582    
204814 ERK1-2-active   transcription agent nucleus active 10493750    
204845 NFATc4   translocation input cytoplasm active 19179536    
204802 mTOR   modification input 19474313    
200269 ERK1-2-active   translocation input cytoplasm active 10493750  8394845    
204817 USP8   modification input 17210635    
204800 AKT1   activation of caspase activity inhibitor plasma membrane active 11027222    
204843 Calcineurin A beta   modification input cytoplasm 19179536    
204836 DOCK7   modification input 18426980    
204804 SHP2   modification input neuromuscular junction 10531446    
204844 NFATc4   modification input cytoplasm 19179536    
204834 STAT3   modification input cytoplasm 11940572    
204807 RAS family  GDP   modification input plasma membrane inactive 11173924    
204248 AKT1   modification input 11027222  10383446  11312610  11546794    
204846 NFATc4   myelination agent nucleus active 19179536    
204805 ErbB2  ErbB3  neuregulin 1 beta   modification input integral to membrane 9694850  9710588    
204816 JUN   transcription agent nucleus active 10582594  10493750  7556067  9049301  10101228    
204818 NRDP1   modification input 17210635    
204815 ERK1-2-active   transcription agent nucleus active 8707830  8702681  10101228    
204797 BAD   modification input 11312610    
204819 ErbB2  ErbB3  neuregulin 1 beta   modification input integral to membrane 17210635  12411582    
204552 PI-4-5-P2   modification input plasma membrane 12750173  10648629  18033240  11136732  11546794  9593664    
204828 PKA   modification input 18799465    
204803 mTOR   myelination agent active 18760695  19535578  19474313  18614687  11564761    
204839 JNK family-active   cell migration agent active 18426980    
204813 ERK1-2-active   transcription agent nucleus active 10493750    
204833 STAT3   modification input cytoplasm 11940572    
204838 JNK family   modification input 18426980    
204847 ErbB2  ErbB3  neuregulin 2   apoptosis inhibitor integral to membrane 12466964    
204798 AKT1   apoptosis inhibitor plasma membrane active 11027222  12466964  8815893    
204794 PI3K Class IA family   modification input cytoplasm 15520002  11027222  9677338  11546794  11312610    
204810 ERK1-2   modification input 18799465  9694850    
204832 JAK2   modification input 11940572