Related Signaling interaction pathway:

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ErbB1 downstream signaling

Related component ;click for the further info from NCBI
SRFRSK2beta 2 chimerinDAGMLC2B
PKC deltamDia240S S6 ribosomal proteinFOXO1AKT1
STAT1STAT3CREB1PDK1JNK1-2-active
p70S6KmTORRHEBGTPRaptor
GBLSOS1Phosphatidic acidMYCMEK1
MEK2RAF1BRAFRAS familyKSR
IQGAP1RALGDSm-calpainERK1-2-activeMKP3
ERK1-2GDPPI-3-4-5-P3WAVE2Nap1
Sra1AbI1PPP2R1APPP2CAPPP2R2A
FOSZFP36PI-4-5-P2PI3K Class IA familyPLD2
ARF4BADSTAT3 (dimer)-activeMKP1EGFR
EGFArp23 complexABI1N-WASP
FOXO3ACaMNHE1MSK1-2MSK1-2-active
MEF2CERK5GRB2JUNPRAS40
TSC1TSC2Rac1RAC1MEK5
Gab1RAB5RIN1BCL-X(L)ELK1
EGR14E-BP1VAV2ATF1Phosphatidylcholine
PLD1CholineMEKK2TsAdSrc
Ca2+IP3RKIPPKC zetaSMAD1
MEKK1ATF2Eps8JNK1-2MKK4
BCL-XLRNTRECDC42YWHAZ14-3-3
14-3-3 familyRALAPP5CmTORC2PKC alpha
Par3

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
204516 SRF   modification input nucleus 8413226    
204605 beta 2 chimerin   translocation input cytoplasm 16628218    
204582 MLC2B   modification input 14747473    
204530 mDia2   filopodium assembly agent active 18516090    
204519 40S S6 ribosomal protein   translational initiation agent 17360704    
203603 FOXO1   modification input nucleus 16020479  18844239  10358075  11030146    
204641 STAT1  STAT3   cell migration agent nucleus active 10469645  15284024    
204517 CREB1   modification input nucleus 8688081  1545823  9770464    
204513 PDK1   modification input 10480933  10856237    
204542 JNK1-2-active   translocation input active   
204567 p70S6K   modification input 19401591  7726827  7637810  16984645    
204588 SOS1   translocation input cytoplasm 17486115    
204521 MYC   cell proliferation agent 3497813  6334806    
204476 MEK1  MEK2   modification input 10567369  19219045    
204594 BRAF   modification input plasma membrane 8073291  19541618    
204515 RSK2   translocation input active 1545823    
204473 BRAF   modification input cytoplasm 17563371  8073291  18567582  14970219  16135787    
204633 RALGDS   translocation input 9550702  15034142    
204619 m-calpain   modification input 14993287  10644690  11319218    
204484 KSR   modification input plasma membrane active 19541618    
204562 FOXO1   pathway input nucleus   
204511 RSK2   modification input 18156174  12832467  10856237    
204490 ERK1-2-active   modification input active 8626780  14690430  17322878  9596579  8910287    
204599 RAF1   modification input plasma membrane active 16508002  19710016    
204589 RAS family  GDP   modification input inactive 17486115    
204600 MEK1   modification input 16508002    
204553 AKT1   modification input cytoplasm 19401591  7637810  15550174  12242303    
204529 mDia2   modification input 18516090    
204486 RAF1   modification input cytoplasm inactive 12932319  16239230    
204499 FOS   degradation input 17322878    
204552 PI-4-5-P2   modification input plasma membrane 12750173  10648629  18033240  11136732  11546794  9593664    
204474 MEK1   modification input 8503013  8248196  7992057  1330321  19541618    
204586 PLD2   modification input 12446727    
204497 FOS   cell proliferation agent nucleus 8248197  9927426  9710644    
204556 BAD   apoptosis inhibitor inactive 19121340  9346240  12832477  15339792    
204481 MEK2   modification input 19541618    
204645 STAT3 (dimer)-active   cell proliferation agent nucleus active 14963038  8071311    
204488 ERK1-2-active   modification input nucleus active 8221888  7939666  7761091  9430728    
204592 PPP2R1A  PPP2CA   modification input 12932319    
204528 Arp2  3 complex   ruffle organization agent plasma membrane active 15039778  14765121  18516090  11777939    
204512 RSK2   modification input 10480933  10856237    
204531 ABI1   modification input active 16155590  14699061    
203610 FOXO3A   modification input nucleus 19401591  10102273    
204611 CaM  NHE1   lamellipodium assembly agent integral to membrane 19341767    
204479 ERK1-2   modification input 19219045    
204505 MSK1-2   modification input 12414794  11018520    
204628 MEF2C   modification input nucleus 11238956  9384584  12640115    
204638 STAT3   modification input cytoplasm 14498832  8378774  8071311  7680434  8524316  7741752  8378775  14963038  8942998  8621573  8397445  8140422    
204554 PDK1   translocation input   
204520 ERK1-2-active   transcription agent active 3497813  6334806  3492494    
204491 MEK1   modification input 19541618    
204642 STAT1  STAT3   cell proliferation agent nucleus active 8524316  8614832    
204509 JUN   cell proliferation agent nucleus active 9407138  3136398    
204565 mTOR  RHEB  GDP  Raptor  GBL  PRAS40   modification input inactive 19401591  16984645  12172553    
204606 Rac1  GTP   modification input plasma membrane active 16628218    
204620 m-calpain   cell migration agent cytoplasm active 14993287  10644690  11319218    
204543 JUN   modification input nucleus 12881422  9315636  9305638  7992057  7600582    
204626 ERK5   modification input 9790194  11073940  12640115    
204560 Gab1   pathway input plasma membrane   
204538 RAB5  GDP   modification input inactive 11703925    
204557 BCL-X(L)   apoptosis inhibitor mitochondria active 19121340  10201527  9346240  9580112    
204602 RAF1  BRAF   modification input active 16508002  8621729    
204503 ELK1   transcription agent nucleus active 19706684  11152283  17322878  11029289  7958858  2189103  2109185    
204570 4E-BP1   pathway input 16984645    
204547 RAC1  GDP   modification input inactive 14699061  12454019    
204507 ATF1   transcription agent nucleus active 3136398  12414794  1653949  9448004  1406636    
204580 Phosphatidylcholine   modification input plasma membrane 7876145  2123453  1637333  9797479  12429840    
204624 MEKK2  TsAd   modification input 12640115    
204610 CaM   modification input 19341767    
204577 Ca2+   modification input calcium store 8940018  19179337    
204576 RKIP  RAF1   modification input 12551925  10891480    
204494 ELK1   modification input nucleus 8386592  9927426  8262053  7889942    
204622 SMAD1   modification input cytoplasm 9335504    
204634 RALGDS   modification input plasma membrane 17079732  17052213  11889038    
204598 ERK1-2   modification input 8248196  17563371  7992057  8226933  11319218  1330321  16135787    
204539 MEKK1   modification input 9305638  7992057  7600581  9733714  7600582    
204568 p70S6K   modification input 12183455  10082559    
204601 MEK2   modification input 16508002    
204585 ARF4  GDP   modification input inactive 12446727    
204587 Phosphatidylcholine   modification input plasma membrane 17486115  9837959    
204613 ATF2   modification input nucleus 12110590    
204475 MEK2   modification input 19541618  19219045    
204524 Eps8  ABI1  SOS1   modification input 15039778  12515821  11777939  10499589    
204541 JNK1-2   modification input 9305638  7992057  7600581  9448004  9733714  7600582  11099046  10499589    
204591 PI-3-4-5-P3   pathway input plasma membrane   
204596 RAF1   modification input plasma membrane active 16407412    
204540 MKK4   modification input 10400627  9889102  9305638  7992057    
204477 ERK1-2   modification input 8248196  7992057  10567369  8226933  1330321  19541618    
204631 BAD  BCL-XL   modification input mitochondria 10597268    
204495 ELK1   modification input nucleus active 8262053  7889942    
204526 WAVE2  Nap1  Sra1  AbI1   modification input 15039778  14765121  11777939  15048123  12181570    
204535 RAB5  GTP   modification input active 11099046    
204583 MLC2B   cell migration agent active 14747473    
204480 MEK1   modification input 7731720  17563371  18567582  14970219  16135787    
204498 ERK1-2-active   transcription agent active 17322878    
204550 MEKK1   modification input 7600581    
204514 RSK2   modification input active 10480933  10856237    
204518 40S S6 ribosomal protein   modification input 17360704    
204644 STAT3 (dimer)-active   translocation input cytoplasm active 8942998  8071311    
204489 ERK1-2-active   transcription agent active 17322878  8910287    
204546 VAV2   translocation input cytoplasm 9438848  12454019    
204472 RAF1   modification input cytoplasm 8180183  11134016  19595761  1990291  9665134  8503013  16093354  18775988  8332195    
204506 ATF1   modification input nucleus 12414794    
204632 BAD   apoptosis inhibitor inactive 10597268    
204522 PI3K Class IA family   modification input inactive 8052307    
204483 MEK1  MEK2   modification input 19219045    
204593 KSR  14-3-3   modification input 12932319    
204640 STAT1  STAT3   translocation input cytoplasm active 8378774  8071311  15284024    
204635 RALA  GDP   modification input inactive 15034142  11889038    
204482 MEK1  MEK2   modification input 8013650  19219045    
204629 ERK5   cell proliferation agent plasma membrane active 9790194  11073940  12640115    
204492 RAF1   modification input plasma membrane active 16892053    
204559 Gab1   translocation input cytoplasm 10648629    
204575 PKC zeta   modification input 12183455  10082559  10891480    
204639 STAT1   modification input cytoplasm active 8378775  8071311  15284024    
204623 SMAD1   pathway inhibitor cytoplasm 9335504    
204485 BRAF   modification input plasma membrane active 19541618    
204643 STAT3   modification input cytoplasm active 8942998  11278353  8378774    
204558 AKT1   modification input active 19401591  15718470    
204478 ERK1-2   modification input 19541618  19219045    
204564 FOXO3A   pathway input nucleus   
204493 ERK1-2-active   translocation input active 17881733  9927426  10567531    
204578 PKC alpha   translocation input cytoplasm inactive 12429840    
204548 CDC42  GDP   modification input inactive 14699061    
204569 40S S6 ribosomal protein   modification input 19401591  12183455  10082559    
204504 EGR1   cell proliferation agent nucleus 11948693  19706684    
204566 4E-BP1   modification input 19401591  16984645    
204527 Arp2  3 complex   modification input plasma membrane 15048123    
204487 ERK1-2-active   transcription agent active 8221888  17322878  14609431  12503606    
204637 STAT1   modification input cytoplasm 8378775  7741752  8621573    
204523 ABI1   modification input 15039778  11099046  10499589    
204579 PLD1   modification input 10441128  9989263  12429840    
204597 MEK1   modification input 16407412    
204636 RALA  GTP   lamellipodium assembly agent plasma membrane active 17079732  15034142    
204607 Par3   modification input 17053785    
204525 RAC1  GDP   modification input inactive 15039778  12515821  11099046  10499589    
204555 BAD  BCL-XL   modification input mitochondria 19121340  10201527  9346240  10082559  9580112    
204549 CDC42  GTP   cytoskeleton organization agent plasma membrane active 14699061    
204581 PKC delta   translocation input cytoplasm inactive 14747473    
204608 Par3   tight junction assembly agent active 17053785    
204532 Arp2  3 complex   modification input plasma membrane 16155590  14699061    
204508 JUN   modification input nucleus 12881422    
204625 MEK5   modification input 12640115    
204614 Src   modification input 12110590  10675331    
204537 RIN1  GDP   modification input inactive 11703925    
204627 ERK5   translocation input plasma membrane active 12640115