Related Signaling interaction pathway:

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Integrins in angiogenesis

Related component ;click for the further info from NCBI
VAV3alphaVbeta3 Integrinc-FMSCbl
CasJAM-AVitronectinFAK1PYK2
PI4 KinasePyk2ERK1-2FGF2ERK1-2-active
Syndecan-1VinculinIRS1IGF-1R heterotetramerIGF1
FibronectinTGFBR2TumstatinVEGFRho
ROCKPI-3Kp27Kip1AKT1VEGFR2 homodimer
VEGFA homodimerSrcDel1LactadherinCaspase 8
CollagenCD47ILKCBLp130Cas
M-CSFPIK3C2APaxillinOsteopontinppsTEM5
RAC1GDPRac1GTPANGPTL3
alphaV beta3 Integrinp70S6KHsp90RhoATalin
PI-4-5-P2SHP2Shp2

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
204336 VAV3   modification input 15711558    
204342 JAM-A   modification input 16418218    
204345 FAK1   modification input cytoplasm 16418218    
204353 PYK2   modification input cytoplasm active 11551924    
204330 ERK1-2   modification input 9490736  12750158    
204381 alphaV  beta3 Integrin  Syndecan-1   cell migration input 15479743  16720645    
204354 IRS1   modification input 16195423    
204387 alphaV  beta3 Integrin  TGFBR2   cell proliferation agent 15187087    
204327 FAK1   modification input cytoplasm 16760434  9182576    
204321 FAK1  Vinculin   cell migration agent cytoplasm active 15247219    
204348 FAK1   modification input cytoplasm 12682293    
204317 FAK1   modification input cytoplasm 16760434  9182576    
204343 PI-3K   modification input plasma membrane 16418218    
204331 ERK1-2-active   angiogenesis agent active 9490736    
204386 alphaV  beta3 Integrin   modification input 15187087    
204324 FAK1   modification input cytoplasm active1 15247219    
204364 p27Kip1   cell adhesion input inactive 12642872  11313365    
204323 FAK1   modification input cytoplasm 15247219    
204325 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 16760434    
204340 alphaV  beta3 Integrin   modification input 9420328  10196194    
204375 alphaV  beta3 Integrin  Lactadherin   cell adhesion agent 10821695    
204374 alphaV  beta3 Integrin   modification input 10821695    
204366 alphaV  beta3 Integrin   modification input 11684710    
204347 alphaV  beta3 Integrin   modification input 12682293  10837460    
204326 PYK2   modification input cytoplasm 16760434    
204383 alphaV  beta3 Integrin   modification input 10037797  8794870    
204361 ILK   modification input 12642872    
204368 alphaV  beta3 Integrin   modification input   
204355 ERK1-2   modification input 16195423    
204335 alphaV  beta3 Integrin   modification input 16600665    
204352 PIK3C2A   modification input 12237112    
204320 FAK1   modification input cytoplasm active 15247219    
204318 FAK1   modification input cytoplasm active 16760434  9182576    
204333 alphaV  beta3 Integrin   modification input   
204362 AKT1   modification input cytoplasm 11313365    
204344 ERK1-2   modification input 16418218    
204378 alphaV  beta3 Integrin  ppsTEM5   regulation of cell-matrix adhesion agent 16982628    
201866 RAC1  GDP   modification input 15711558    
204372 alphaV  beta3 Integrin   modification input 11877390    
204341 FAK1   modification input cytoplasm 10196194    
204356 p70S6K   modification input cytoplasm 16195423    
204346 alphaV  beta3 Integrin  JAM-A   modification input 12750158    
204373 alphaV beta3 Integrin  ANGPTL3   cell adhesion agent 11877390    
204316 VEGFR2 homodimer  VEGFA homodimer   modification input plasma membrane active 15247219  10022831  16760434    
204359 alphaV  beta3 Integrin   modification input   
204363 p27Kip1   modification input 12642872  11313365    
204319 FAK1  Paxillin   cell migration agent cytoplasm active 16760434  9182576    
204380 alphaV  beta3 Integrin   modification input 15479743  16720645    
204334 alphaV  beta3 Integrin  Osteopontin   subnet input   
204384 alphaV  beta3 Integrin  CD47   cell adhesion agent 10037797    
204377 alphaV  beta3 Integrin   modification input 16982628    
204357 IGF-1R heterotetramer  IGF1  IRS1   modification input 16195423    
204367 alphaV  beta3 Integrin  Caspase 8   apoptosis agent 11684710