Related Signaling interaction pathway:

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Ceramide signaling pathway

Related component ;click for the further info from NCBI
NF kappa B1RelAI kappa B alphaI kappa B alpha (degradation)PP2A Heterotrimer
MYCIKKsMAP4K4JNK1MKK4
PKC zetaceramideBIDCathepsin DTNF-alpha
TNFR1ATRADDMADDcIAP2RIP1
TRAF2RAIDDBAG4ERK1ERK2
MEK1MEK2Cytochrome CBCL2RAF1
KSRsphingomyelinAcid SphingomyelinaseEGFSphingosine
SPHK2Sphingosine-1-phosphateNeutral sphingomyelinase IIFANglutathione
AIFMEKK1PKRRAXBAX
GD3GW4869C11AGPHOSPHOCHOLINERB1
BADPKC deltaAKT1PAR4FADD
Caspase 8IGF1Acid CeramidasePDGFAFree Fatty acid
OKADAIC ACIDeIF2A

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
203841 NF kappa B1  RelA  I kappa B alpha   modification input cytoplasm inactive   
203874 PP2A Heterotrimer   transcription inhibitor mitochondria active 8387486    
203839 IKKs   modification input   
203865 JNK1   modification input cytoplasm 8702918  10962008    
203889 BID   modification input cytoplasm 14739942    
203838 MAP4K4   modification input   
203835 TNFR1A  BAG4   modification input   
203848 ERK1   modification input cytoplasm 7559390    
203861 Cytochrome C   translocation input mitochondria 9873064    
203846 RAF1   modification input 7477354    
203854 sphingomyelin   modification input   
203868 Sphingosine   modification input   
203851 Acid Sphingomyelinase   modification input   
203843 Neutral sphingomyelinase II   modification input 10026132  14670935  9488730    
203879 BCL2   modification input 10400650    
203862 AIF   translocation input mitochondria   
202585 MEKK1   modification input 15164763    
203885 PKR   modification input 7519779    
203855 BAX   modification input 10438487    
203844 sphingomyelin   modification input 12866359  12566438  10395296  12154098  15051724    
203836 TNFR1A  BAG4  TNF-alpha   modification input   
203864 MKK4   modification input cytoplasm   
203873 RB1   negative regulation of cell cycle agent inactive   
203849 Acid Sphingomyelinase   modification input 14689449  15881228    
203871 Sphingosine   apoptosis input   
203858 AIF   translocation input mitochondria 12486111    
203866 TNF-alpha   modification input extracellular region 8808629    
203859 Cytochrome C   translocation input mitochondria   
203884 RAX   modification input 11148216    
203872 RB1   modification input active   
203882 ERK1  PKC delta   cell proliferation agent   
203888 Cathepsin D   modification input 10508159    
203890 NF kappa B1  RelA   regulation of nitric oxide biosynthetic process agent cytoplasm 9446561    
203870 Sphingosine   MAPKKK cascade input   
203853 Acid Sphingomyelinase   modification input   
203883 AKT1   modification input cytoplasm 11723139    
203856 BAD   modification input   
203840 NF kappa B1  RelA  I kappa B alpha   modification input cytoplasm inactive   
203837 FADD  Caspase 8   modification input 8681376  8681377    
203881 ERK1   modification input cytoplasm active 11350735    
203867 ceramide   modification input   
203852 Acid Sphingomyelinase   modification input   
203891 ceramide   ganglioside biosynthetic process agent 9287216    
203857 Cytochrome C   translocation input mitochondria   
203875 PP2A Heterotrimer   modification input mitochondria 8393446    
203845 KSR   modification input 9094715    
203869 SPHK2   modification input   
203878 PKC zeta  ceramide   cell survival agent   
203860 AIF   translocation input mitochondria   
203886 eIF2A   modification input   
203847 MEK1   modification input cytoplasm 8933152  10969079    
203850 Acid Sphingomyelinase   modification input   
203842 Caspase 8   modification input cytoplasm active   
203877 PKC zeta   modification input 15901738    
203887 eIF2A   regulation of translation input inactive 10433354    
203880 BCL2   apoptosis input inactive