Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



TNF receptor signaling pathway

Related component ;click for the further info from NCBI
TNFR2TACETNFR2 (cleaved)sTNF-alphaTNFR1A
TRADDRIPTRAF2STAT1CYLD
RIP1STAT1 (dimer)Caspase 8 (cleaved)TNF-alphaTRAF1
MADDIKK complexMKK7ASK1p62
Atypical PKCsMEKK1TAK1TAB familyMEKK3
ASMFADDceramideFANNSMASE
RFFLCaveolin-1MKK3Group I GCKsTRX
thioredoxinA20NF kappa B1RelANF kappa B1 p50
Caspase 8cIAP1cIAP2RACK1sphingomyelin
BAG4

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
203442 TNFR2   modification input 10510344    
203435 sTNF-alpha  TNFR1A  TRADD   modification input integral to membrane active 12917690  16543241  10848577  16603398  8565075  8612133  12917689  9915703  12917691    
202103 Caspase 8 (cleaved)   pathway input active   
203436 TNF-alpha  TNFR2 (cleaved)   modification input integral to membrane 8069916    
203472 sTNF-alpha  TNFR1A  MADD   MAPKKK cascade agent integral to membrane active 9115275    
202109 IKK complex   pathway input active   
203461 MKK7   JNK cascade agent cytoplasm active 10801798  9774977  9275185  9405407  8974401  9384583    
203463 MKK7   modification input cytoplasm 8974401    
203443 sTNF-alpha  TNFR1A  TRADD  RIP1  TRAF2   modification input integral to membrane active 10356400    
203460 MKK7   modification input cytoplasm 9384583    
203439 IKK complex   modification input 11429546  10795740  16260783  15218148    
203457 RIP   proteasomal ubiquitin-dependent protein catabolic process input endosome inactive 18450452    
203447 RIP   proteasomal ubiquitin-dependent protein catabolic process input inactive 15258597    
203454 ASM   modification input 10026132  10187805  7923351    
202128 ceramide   pathway input 11031259  16636669    
203467 sTNF-alpha  TNFR1A   modification input integral to membrane active 8808629    
203438 sTNF-alpha  TNFR1A  TRADD  RIP1  TRAF2  TAK1  TAB family   modification input integral to membrane active 11429546  16260783    
203448 sTNF-alpha  TNFR1A  TRADD  RIP1  TRAF2   modification input endosome active 18450452    
203441 sTNF-alpha  TNFR1A  TRADD  RIP1  TRAF2   translocation input integral to membrane active 15793306  10187805    
203451 sTNF-alpha  TNFR1A  TRADD  TRAF2   modification input endosome active 8565075  17024246  15357952    
203466 MKK3   modification input 9712898  9639556    
203450 TRAF2   proteasomal ubiquitin-dependent protein catabolic process input inactive 11907583    
203459 MEKK1   modification input 9712898    
203434 sTNF-alpha  TNFR1A   modification input integral to membrane active 7758105  9915703    
203462 TRX  ASK1   modification input inactive 9774977  8974401  9564042    
203446 sTNF-alpha  TNFR1A  TRADD  RIP1  TRAF2   modification input endosome active 8692885  15258597    
203437 sTNF-alpha  TNFR1A  TRADD  RIP1  TRAF2   modification input integral to membrane active 16260783  16543241  16603398    
203464 MKK3   modification input 8974401    
203432 TNF-alpha   modification input integral to membrane 8521496    
203465 MKK3   pathway input active 10097111  8974401    
203444 NF kappa B1  RelA   modification input 11684013  10356400    
203431 TNF-alpha   modification input integral to membrane 9034190    
203470 sTNF-alpha  TNFR1A   modification input integral to membrane active 9115275    
203458 Group I GCKs   modification input 9712898  9405407    
203452 Caspase 8   modification input 17024246  15357952  8681376    
203468 sTNF-alpha  TNFR1A  FAN  NSMASE   modification input integral to membrane active 12391233    
203471 sTNF-alpha  TNFR1A  MADD   JNK cascade agent integral to membrane active 9115275    
202127 sphingomyelin   modification input 11031259  1313189  16636669    
203449 sTNF-alpha  TNFR1A  TRADD  RIP1  TRAF2   modification input integral to membrane active 8943045  12077366  11907583    
203433 sTNF-alpha   modification input extracellular region 2158863  9915703