Related Signaling interaction pathway:

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IGF1 pathway

Related component ;click for the further info from NCBI
IGF-1R heterotetramerIGF1IRS1GRB2Sos
ShcRACK1SHCGRB10HRAS
GDPGTPPKC muPI-3KSOS1
BADAKT1Crkp130 CasPaxillin
FAK1p70S6K14-3-3PKC zetaPDK1
RAF1CRK14-3-3 EYWHAZSHP2
Shp2PTP1BPKC deltaIRS2NCK2
IRSNckCRKL

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
203330 IGF-1R heterotetramer  IGF1   translocation input 15003536    
203346 IGF-1R heterotetramer  IGF1  GRB2  Sos  Shc   modification input 11884618  15611085    
203356 IGF-1R heterotetramer  IGF1   modification input 9506989  8798417  8776723  8764099    
203333 HRAS  GDP   modification input inactive   
203353 PKC mu   modification input 11884618    
200592 PI-3K   pathway input plasma membrane active   
203331 IGF-1R heterotetramer  IGF1  IRS1   modification input caveola   
203329 IGF-1R heterotetramer   modification input 7540132  1378290    
203358 BAD   modification input cytoplasm 10490655  9346240    
203351 Crk  p130 Cas  Paxillin   modification input 9748296    
203360 BAD  14-3-3   apoptosis inhibitor 9346240  16932738    
203343 PKC zeta   modification input 14604996    
203335 RAF1   modification input cytoplasm   
203350 CRK   modification input cytoplasm 9442079  9346905  9748296    
203338 RAF1   modification input cytoplasm inactive 12048182  10576742    
203332 IGF-1R heterotetramer  IGF1   modification input   
203359 BAD   modification input cytoplasm inactive 10490655  16932738    
203344 SHP2   modification input 11572799    
203362 IGF-1R heterotetramer  IGF1   modification input 15976035  11836447    
203342 p70S6K   modification input 14550766  12538620  9748296  15070696    
203352 PKC delta   modification input 11884618    
203340 PDK1   modification input plasma membrane 12538620    
203337 RAF1   modification input cytoplasm active 12048182  10576742    
203336 RAF1  14-3-3 E   positive regulation of MAPKKK cascade inhibitor 12048182    
203341 AKT1   translocation input cytoplasm 12538620    
203348 IRS1  Crk   modification input 7534289  8621590  9480911    
203349 IRS2  Crk   modification input 8621590    
203339 PI-3K   modification input plasma membrane 12538620    
203364 IGF-1R heterotetramer  IGF1   modification input 8265614    
203334 HRAS  GDP   modification input inactive   
203355 SHP2   modification input 7513703  8505282  8662827  7642582    
203347 CRKL   modification input 9346905