Related Signaling interaction pathway:

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CXCR4-mediated signaling events

Related component ;click for the further info from NCBI
LCKSTAT2STAT2 (dimer)Ca2+PKC zeta
MMP9RhoA-B-CGTPHGSITCH
VPS4GDPG13IP3SDF1
CXCR4JAK2CXCR4 (dimer)G betagamma
PLIC-1LIMK1PAK1RAC1-CDC42PI3K Class I family
RALBPLC betaGNB1GNG2Cofilin
SHH1LIntegrin beta 1-Integrin alphaRGS1Gi familySSH1L
RAP1BFAKp130 CasPaxillinSTAT1-3-5
STAT1-3-5-activeGRK2Src Family Kinases-activePI-4-5-P2DAG
PI-3-4-5-P3SHIPPI-3-4-P2STAT1-3-5 (dimer)CD45
AKT1mTORC2RAP2A-BPYK2CRK
beta Arrestin3DNM1PDK1BADFOXO1
TCRCD3MHC IICD4CSK
PAG1VAV1alpha4beta1 IntegrinSrc Family Kinase
Src Family Kinase-activePTENSHP1-2GRK6beta Arrestin2
RACK1

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
203253 LCK   chemotaxis agent active 12519755  16503409    
203301 STAT2   modification input cytoplasm 10506573  11369622    
203282 Ca2+   chemotaxis agent cytoplasm 17675482    
203274 PKC zeta   transcription agent plasma membrane active 15630457    
203266 RhoA-B-C  GTP   chemotaxis agent active 17056591    
203327 HGS   modification input endosome 14602072    
203275 PKC zeta   cell proliferation agent plasma membrane active 15630457    
203267 RhoA-B-C  GDP   modification input inactive 17056591    
203302 STAT2 (dimer)   translocation input cytoplasm active 10506573  11369622    
200251 Ca2+   translocation input calcium store 3919143  15879121  17675482  9820480  19158393  9722546  12598525  17242406  9398617  12482967  9115251  9435453  8125934    
203300 STAT2   modification input cytoplasm 10506573  11369622    
203318 SDF1   modification input extracellular region 18799424    
203289 SDF1  CXCR4   receptor internalization input integral to membrane active 14662753  19380820    
203305 LIMK1   modification input 11784854    
203286 RAC1-CDC42  GTP   establishment of cell polarity agent active1 15618472    
203294 SDF1  CXCR4   modification input integral to membrane active 15615703  10506573    
203257 PI3K Class I family   establishment of cell polarity agent plasma membrane active 10491003    
203292 RALB  GDP   modification input inactive 18227351    
203271 PKC zeta   modification input cytoplasm 18596232  15630457    
203279 PLC beta   modification input cytoplasm 17675482    
203308 Cofilin   modification input inactive 16230460    
203306 Cofilin   modification input 11784854    
203270 Integrin beta 1-Integrin alpha   regulation of heterotypic cell-cell adhesion input 15728464    
203328 Gi family  GTP   cAMP biosynthetic process inhibitor cytoplasm active 10644702    
203312 LIMK1   positive regulation of lamellipodium assembly agent 16230460    
203307 SSH1L   translocation input 16230460    
203320 RAP1B  GDP   modification input inactive 18319399  17568820    
203295 STAT1-3-5   modification input cytoplasm 15615703  10506573    
203323 SDF1  CXCR4   modification input integral to membrane active 10521508    
203309 LIMK1   chemotaxis agent 11784854  16230460    
203268 FAK   modification input 15728464  12590707  11369622  10753828    
203280 PI-4-5-P2   modification input plasma membrane 17675482  18596232    
200936 PI-3-4-5-P3   modification input plasma membrane 16038794  10606629  7556092    
203296 STAT1-3-5-active   modification input cytoplasm active 10506573    
203251 SDF1  CXCR4   modification input integral to membrane active 12519755  16503409    
203269 RGS1   chemotaxis inhibitor 15728464    
203319 SDF1  CXCR4 (dimer)   chemotaxis inhibitor integral to membrane active 18799424    
203262 AKT1   modification input plasma membrane active 12682230  16919458  11136732  18596232  16962653  12750173  10570282  15718470    
203297 STAT1-3-5 (dimer)   translocation input cytoplasm active 10506573    
203290 RAP2A-B  GDP   modification input inactive 12133960    
203263 AKT1   chemotaxis agent plasma membrane active 12682230  10491003  12535795    
203326 SDF1  CXCR4   degradation input lysosome inactive 14602072  11641392    
203247 PYK2   modification input 18319399  11369622  9722546    
203246 GNB1  GNG2   modification input cytoplasm active 14662753    
203291 RAP2A-B  GTP   chemotaxis agent active 12133960    
203324 SDF1  CXCR4   translocation input integral to membrane inactive 14602072  10521508    
203261 AKT1   modification input cytoplasm 12750173  11136732  18596232  10570282    
203276 BAD   modification input 11544290    
203277 FOXO1   modification input nucleus 11544290    
203325 SDF1  CXCR4   modification input endosome inactive 11641392    
203311 SHH1L   establishment of cell polarity agent filamentous actin 16230460    
203288 TCR  CD3  MHC II  CD4  LCK   pathway input integral to membrane active 16919488    
203245 G13  GDP  G beta  gamma   modification input inactive 17056591    
200922 LCK   modification input 1639064  12036857    
203243 SDF1   modification input extracellular region 8752281  8752280    
203249 LCK   modification input 12036857    
203285 RAC1-CDC42  GDP   modification input inactive 15872091  15618472    
203259 PI3K Class I family   modification input 12682230  9722546  10570282    
203244 Gi family  GDP  G beta  gamma   modification input inactive 17056591    
203310 Cofilin   actin filament depolymerization agent filamentous actin 16230460    
203284 SDF1  CXCR4   modification input integral to membrane active 15618472    
203317 Integrin beta 1-Integrin alpha   cell adhesion input 12590707  17568820    
203272 PKC zeta   chemotaxis agent plasma membrane active 18596232  15630457    
203316 alpha4  beta1 Integrin   cell adhesion input 15872091  10952719    
203248 PYK2  Paxillin  CRK   chemotaxis agent 10881171    
203255 Src Family Kinase   modification input 17056591  15728464  12590707    
203265 PAK1   modification input cytoplasm 17056591    
203273 Integrin beta 1-Integrin alpha   regulation of heterotypic cell-cell adhesion input 15630457    
203260 PI-4-5-P2   modification input plasma membrane 15994292  12682230  12077227  9722546  10570282    
203252 LCK   modification input inactive 12519755    
203298 SDF1  CXCR4   modification input integral to membrane active 10506573  11157475    
203264 RAC1-CDC42  GDP   modification input inactive 17056591    
203299 SDF1  CXCR4  SHP1-2   chemotaxis agent integral to membrane active 10506573  11157475    
203303 PI3K Class I family   modification input 11369622    
203321 SDF1  CXCR4   modification input integral to membrane active 12032308  14704365    
203322 SDF1  CXCR4   translocation input integral to membrane inactive 14602072  12032308  10521508  10644702    
203287 TCR  CD3  MHC II  CD4   modification input integral to membrane active 16919488  17537990    
203293 RALB  GTP   chemotaxis agent active 18227351    
203278 GNB1  GNG2   modification input cytoplasm active 18596232