Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



IL2-mediated signaling events

Related component ;click for the further info from NCBI
IL2IL2R alphabetagammaJAK1
LCKJAK3SHCGRB2SOS1
GAB2SHP2PI3KCDK2Aiolos
BCL2IL2R betaIL2R gammaSOCS1SOCS3
CISHPYK2JNK1-2STAM1-2IRS1-2
FynSTAT3MEK1-2STAT3 (dimer )RhoA
GDPGTPPI-3KSYKERK1-2-active
PP2ARAS familyRasGAPDok-RPKC epsilon
SOCS2MAPKAPK2p38alpha-beta-activeRAF1PKC beta
STAT1STAT1 (dimer)ERK1-2STAT5STAT5 (dimer)-active
MYCIFN-gammaFOSJUNp38alpha-beta

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
203238 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  SHC  GRB2  SOS1  GAB2  SHP2  PI3K   subnet input integral to membrane active   
203193 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  SHC   modification input integral to membrane active 8119884  10982827  8294403    
203206 CDK2   G1/S transition of mitotic cell cycle agent nucleus active 10962581    
203232 Aiolos   transcription agent nucleus active 10369681    
203188 IL2   modification input extracellular region 9391116  8552611  7988557  9202126  1631559  2590941  2303462  10514520  1545122  1940342  1618313  8262551  7973658  9822600  2106566  3095922  8702919  10373548  7973659  7665592  2047859  9382798  10214954  7973657    
203212 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  PYK2   cell proliferation agent integral to membrane active 9512511    
203219 JNK1-2   modification input 10066828  9169478    
203223 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3   modification input integral to membrane active 10899310  9133424    
203227 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3   modification input integral to membrane active 7499365    
203201 SOCS3   modification input 10373548  11331873    
203213 IL2   modification input extracellular region 8483935    
203190 STAT3   modification input cytoplasm 7528668  7719938  12681450  10602027  9305919  7544001  7719937  7568001    
203240 IL2  IL2R beta  gamma  JAK1  LCK  JAK3  PI3K   subnet input integral to membrane active   
203207 RhoA  GDP   modification input inactive 9029085    
203226 PI-3K   modification input 12393431    
203205 CDK2   translocation input cytoplasm 10962581    
203192 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3   modification input integral to membrane active 9794391  8700888  7688728  8643566  8294403    
203242 PP2A   positive regulation of cell-cell adhesion input 9195132    
203194 RAS family  GDP  Aiolos   modification input plasma membrane inactive 1460037  1532814  11331873  9697832  10369681    
203230 Dok-R   modification input 9697832    
203235 PKC epsilon   T cell proliferation agent cytoplasm active 7737351    
203203 IL2R beta  JAK1  LCK  SOCS3   modification input integral to membrane active 16199887    
203211 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3   modification input integral to membrane active 9512511    
203218 MAPKAPK2   modification input 10066828  9169478    
203202 SOCS3   modification input active 11331873    
203229 Dok-R   modification input 9697832    
203228 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  IRS1-2   modification input integral to membrane active 7499365    
203196 MEK1-2   modification input cytoplasm 7760801  12543077  10962581    
203204 IL2R beta  JAK1  LCK  SOCS3  SOCS2   proteasomal ubiquitin-dependent protein catabolic process agent integral to membrane inactive 16199887    
203220 p38alpha-beta-active   T cell proliferation agent active 9169478    
203231 Aiolos   translocation input cytoplasm active 10369681    
203195 RAF1   modification input plasma membrane 1996324  1708096  8805624  1639773    
203234 PKC beta   modification input 7737351    
203189 STAT1   modification input cytoplasm 7719937  7544001  10602027    
203187 IL2   modification input extracellular region 8552611  1631559  2590941  2303462  1545122  1618313  8262551  7973658  10962026  2106566  9822600  10421845  9092570  7665592  2047859  10214954  7973657    
203208 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  SHC  GRB2  SOS1  GAB2   modification input integral to membrane active 9590209  9973481  15170389  10849428  15356145    
203209 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  SHC  GRB2  SOS1  GAB2  SHP2   modification input integral to membrane active 8025955  9973481  1655887  10982827  9029085  7509794  10849428    
203214 IL2  IL2R beta  gamma  JAK1  Fyn  JAK3   modification input integral to membrane active 1652056    
203200 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3   transcription agent integral to membrane active 10373548    
203225 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3   modification input integral to membrane active 10825200  7600304  12393431    
203233 PKC epsilon   modification input cytoplasm 7737351    
203191 STAT5   modification input cytoplasm 9822600  8702919  7988557  7777534  7719938  7543676  10373548  10602027  10514520  8700888  7479881  7719937  9382798  7568001  7781605    
203224 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  STAM1-2   transcription agent integral to membrane active 10899310  10993906  9133424    
203197 ERK1-2   modification input cytoplasm 1381507  8376945    
203241 PI-3K   subnet input active   
203236 PKC beta   T cell proliferation agent active 7737351    
203222 ERK1-2-active   transcription agent cytoplasm active 10843677  6434688    
203198 ERK1-2-active   transcription agent cytoplasm active 1460037  15170389  7568005  1535827    
203199 ERK1-2-active   transcription agent cytoplasm active 1460037  1535827    
203239 IL2  IL2R alpha  beta  gamma  JAK1  LCK  JAK3  SHC  GRB2  SOS1  GAB2  SHP2  PI3K   subnet input integral to membrane active   
203221 ERK1-2-active   natural killer cell mediated cytotoxicity agent cytoplasm active 10843677  6434688    
203237 STAT5 (dimer)-active   subnet input nucleus active   
203217 p38alpha-beta   modification input 10066828  9169478    
203210 IL2  IL2R beta  gamma  JAK1  LCK  JAK3   modification input integral to membrane active 1655887  10421845  8397196  9092570