Related Signaling interaction pathway:

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Angiopoietin receptor Tie2-mediated signaling

Related component ;click for the further info from NCBI
NCK1Dok-RPAK1ROSRac1
GTPPlasminTie2Ang1L-arginine
NADPHO2eNOSL-citrullineNO
NADPELK1ERK1-2-activePI-3KAng2
p38 alphaSHCShcCRKCrk
FESp70S6KTNF-alphaThrombinbeta2-estradiol
ETS1GRB2NERF2PhosphatidylcholinePLD
Phosphatidic acidCholineMMP2BMXRAC1
GDPElf1PaxillinFAK1p21CIP1
RasGAPGRB7ABIN2SHP2FOXO1
AKT1STAT5A (dimer)GRB14Angiotensin IIAT1
FGF2Ang1-4FynNF kappa BRelA
JNK1alpha5beta1 IntegrinSTAT5beta 1 Integrin
FibronectinERK1-2

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
202480 NCK1  Dok-R   modification input 16049136  11689432  9764820    
202516 Plasmin   translocation input cytoplasm 10807867    
202524 L-arginine   modification input cytoplasm 10908731  10376602  11978735  12171920  17466390  15162796  10376603    
202505 ELK1   modification input 12824293    
202541 PI-3K   modification input cytoplasm   
202506 p38 alpha   modification input 12824293    
202491 Tie2  Ang1   modification input transmembrane active 14665640    
202483 Dok-R   modification input 9764820    
202543 FES   modification input cytoplasm 11801735    
202539 PI-3K   modification input cytoplasm 11801735  16061664    
202510 Tie2  Ang1   translocation input transmembrane active 12890486    
202481 NCK1  PAK1  Dok-R   cell migration agent 16049136  11689432    
202544 p70S6K   cell proliferation input cytoplasm active 16061664    
202474 TNF-alpha   transcription agent extracellular region 15350545    
202475 PI-3K   modification input cytoplasm 14665640  9632797  10585289    
202490 Tie2  Ang1   modification input transmembrane active 14749497  10521483    
202518 Tie2  Ang1   transcription agent transmembrane active 11967990    
202512 Phosphatidylcholine   modification input 12890486    
202517 MMP2   translocation input cytoplasm 10807867    
202535 BMX   modification input cytoplasm 11416142    
202499 RAC1  GDP   modification input inactive 12816861    
202520 NERF2   transcription agent 11157678  10347092  12117724    
202498 Paxillin   focal adhesion formation input cytoplasm active 17189382  10807867    
202514 FAK1   modification input cytoplasm 10807867    
202473 Tie2   modification input transmembrane 11230987  16895971  15284220  11166279  9204896    
202503 p21CIP1   negative regulation of cell cycle agent   
202540 p70S6K   modification input cytoplasm 16061664    
202482 Dok-R   modification input 12665569  9478921  9764820    
202484 Tie2  Ang1   modification input transmembrane active 10521483    
202492 Tie2  Ang1  Shc   chemokinesis agent transmembrane active   
202546 Tie2  Ang1   modification input transmembrane active 12609966    
202485 Tie2   modification input transmembrane 14749497  15985432    
202545 FOXO1   modification input 15132996    
202536 FES   modification input cytoplasm 16061664    
202472 Tie2   modification input transmembrane 8980223  11513602  16895971  15769741  10051567  9204896    
202502 STAT5A (dimer)   transcription agent nucleus active 14726409  9926914    
200521 Paxillin   modification input cytoplasm 10807867  7510708  7527052  7561682    
202488 Tie2  Ang1   modification input transmembrane active 10521483    
202521 Angiotensin II  AT1   transcription agent 11139469  11289054  10944458    
202493 Rac1  GTP   chemokinesis agent active   
202538 Fyn   tube development agent cytoplasm active 11801735    
202547 NF kappa B  RelA   modification input cytoplasm active 12609966  12933576    
202523 eNOS   modification input cytoplasm 10376603  12759249    
202478 JNK1   modification input 16049136    
202495 Tie2  Ang1  alpha5  beta1 Integrin   cell migration agent transmembrane active 16157706    
202542 Fyn   modification input cytoplasm 11801735    
202513 PLD   MAPKKK cascade agent caveola active 12890486    
202501 STAT5   modification input 14726409    
202477 AKT1   negative regulation of caspase activity agent plasma membrane active 12074640  15242771  12824293    
202479 Dok-R   modification input 12665569  11689432  9764820    
202476 AKT1   modification input 10625301  9632797  10585289    
202507 p38 alpha   modification input 12824293    
202494 Tie2  Ang1   modification input transmembrane active 17189382    
202511 PLD   modification input caveola 12890486    
202504 ERK1-2   modification input 12824293  16049136  12890486    
202525 NO   vasculogenesis agent 12759249