Related Signaling interaction pathway:

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Signaling events regulated by Ret tyrosine kinase

Related component ;click for the further info from NCBI
RET51GFRalpha1GDNFRac1GTP
PI-3KRET9FRS2SHP2GRB2
Grb2Shank3Dok5SHCGab1
GAB1HRASGDPDOKRasGAP
NCKDOK1IRS1NCK1ERK1-2
RAP1AERK1-2-activeJUNJNK1SOS1
CREB1Dok4IRS2Dok6Src
p62DOKRAC1PKC alphaPKAFAK1
RhoAGRB10GRB7Grb7Crk
p130 CasPaxillinEnigma

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
202135 RET51  GFRalpha1  GDNF   translocation input transmembrane   
200503 Rac1  GTP   lamellipodium assembly agent active 12973357  12589802  11886862  12393875  18033240  15793570  15351743    
202184 PI-3K   modification input plasma membrane 11886862    
202143 RET9  GFRalpha1  GDNF  FRS2   modification input membrane raft 11360177    
202178 RET9  GFRalpha1  GDNF   modification input transmembrane 15569713    
202195 RET51  GFRalpha1  GDNF   modification input transmembrane 11470823    
202155 RET9  GFRalpha1  GDNF  SHC   modification input transmembrane 11002419    
202167 HRAS  GDP   modification input inactive 12087092    
202150 PI-3K   modification input plasma membrane 11313948    
202179 RET9  GFRalpha1  GDNF  Shank3   tube development agent transmembrane 15569713    
202166 RET51  GFRalpha1  GDNF  DOK1   modification input transmembrane 10448070  11470823  12087092    
202144 RET9  GFRalpha1  GDNF  FRS2  SHP2  Grb2   activation of MAPKK activity agent membrane raft 9632781  11390647  9182757    
202193 ERK1-2   modification input 16820412    
202170 JUN   modification input nucleus 9891069  10882101  12087092    
202134 RET51   modification input transmembrane 2181380  7478523  12063395    
202160 RET51  GFRalpha1  GDNF  SHC   modification input transmembrane 11002419  8570170    
202137 RET51  GFRalpha1  GDNF  FRS2   modification input membrane raft 9632781  11360177    
202163 CREB1   modification input 11002419    
202161 RET9  GFRalpha1  GDNF  SHC   modification input transmembrane 11002419  8570170    
202141 RET9  GFRalpha1  GDNF   translocation input transmembrane   
202191 RET51  GFRalpha1  GDNF   modification input transmembrane 16820412  11470823    
202149 PI-3K   modification input plasma membrane 11002419  11000521  15351743    
202162 CREB1   modification input 11002419    
202189 RET51  GFRalpha1  GDNF   modification input transmembrane 15286081    
202156 PI-3K   modification input plasma membrane 11002419  11000521  15351743    
202180 RET9  GFRalpha1  GDNF  Shank3   modification input transmembrane 15569713    
202194 ERK1-2-active   neurite development agent active   
202165 RET51  GFRalpha1  GDNF   modification input transmembrane 14607833  10448070  12087092    
202152 RAC1  GDP   modification input inactive 17050626  15351743    
202174 RET51  GFRalpha1  GDNF   modification input transmembrane 12771945    
202181 RET9  GFRalpha1  GDNF  Shank3  Grb2   MAPKKK cascade agent transmembrane 15569713    
202132 RET9   modification input transmembrane 8674117  16227613    
202192 RAP1A  GDP   modification input inactive 16820412    
202154 RET9  GFRalpha1  GDNF   modification input transmembrane 9047384  11313948  9047383  11000521    
202183 RET51  GFRalpha1  GDNF   modification input transmembrane 15966897  17050626  11886862    
202151 PI-3K   pathway input plasma membrane active 11002419    
202138 RET51  GFRalpha1  GDNF  FRS2  SHP2  Grb2   activation of MAPKK activity agent membrane raft 9632781  11390647  9182757    
202182 RET9  GFRalpha1  GDNF  Shank3  Grb2   tube development agent transmembrane 15569713    
202136 RET51  GFRalpha1  GDNF   modification input membrane raft 11360177  11390647    
202171 JUN   JNK cascade agent nucleus active 12087092    
200510 HRAS  GTP   MAPKKK cascade agent active 9405464  12087092  7809106    
202147 RET51  GFRalpha1  GDNF   modification input transmembrane 9047384  11313948  9047383  11000521    
202190 RET51  GFRalpha1  GDNF  Dok6   neurite development agent transmembrane 15286081    
202187 FAK1   modification input 16153436  15657578  10208419    
202157 PI-3K   modification input plasma membrane 11313948    
202172 RET51  GFRalpha1  GDNF   modification input transmembrane 8631863  7665556    
202142 RET9  GFRalpha1  GDNF   modification input membrane raft 11360177  11390647    
202186 Crk  p130 Cas  Paxillin   modification input 10208419    
202148 RET51  GFRalpha1  GDNF  SHC   modification input transmembrane 11002419    
202177 RET9  GFRalpha1  GDNF   modification input transmembrane 8662982  12176011    
202158 PI-3K   modification input plasma membrane 15569713    
202169 JNK1   modification input 12087092