Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



TRAIL signaling pathway

Related component ;click for the further info from NCBI
TRAILTRAILR1DAP3GTPFADD
TRAILR2TRADDRIPCaspase 8CFLAR
Caspase 8 (cleaved)TRAILR4JNK1MKK4ASM
TRAF2IKK complexPro-Caspase 10TRAILR4 (trimer)Caspase 10 (cleaved)
TRAIL (trimer)ceramidePI3K Class IA familyTRAILR2 (trimer)MEKK1
TRAILR3 (trimer)TRAILR3TRAILR1 (trimer)ERK1-2-activeERK1-2
RIP (cleaved)sphingomyelin

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
202101 TRAIL  TRAILR1  DAP3  GTP   modification input integral to membrane 11376335    
202106 TRAIL  TRAILR2  FADD   modification input integral to membrane 9430227  16940186    
202097 Caspase 8   modification input 9311998  10894160  16940186  15105837  10894161  10783243    
202094 TRAIL  TRAILR4   positive regulation of NF-kappaB transcription factor activity agent integral to membrane 9430226    
202103 Caspase 8 (cleaved)   pathway input active   
202120 JNK1   modification input 10958661  10521444    
202126 ASM   modification input 16636669    
202116 TRAIL  TRAILR2  FADD  TRADD  RIP   modification input integral to membrane 10958661  10521444    
202109 IKK complex   pathway input active   
202099 Pro-Caspase 10   modification input 9311998  16980609  9242610  16319225    
202107 IKK complex   modification input 9430227  11461927  10958661    
202098 Pro-Caspase 10   modification input 9311998  9242610    
202093 TRAIL (trimer)   modification input extracellular region 9430226    
202128 ceramide   pathway input 11031259  16636669    
202113 PI3K Class IA family   modification input plasma membrane 12668516    
202122 TRAIL  TRAILR4   JNK cascade agent integral to membrane 16227629  10521444    
202091 TRAIL (trimer)   modification input extracellular region 9311998  9242610    
202095 TRAIL  TRAILR1   modification input integral to membrane 10894160  10894161  10783243    
202118 MEKK1   modification input 10521444    
202115 TRAIL  TRAILR1  FADD  TRADD  RIP   modification input integral to membrane 10958661  10521444    
202108 IKK complex   modification input 9430227  11461927  10958661    
202092 TRAIL (trimer)   modification input extracellular region 16980609  9314565  9242610    
202090 TRAIL (trimer)   modification input extracellular region 9082980    
202117 MEKK1   modification input 10521444    
202112 Caspase 8   modification input 9311998  10894160  11376335  16940186  10894161  11278665  10783243    
202111 ERK1-2   modification input 12668516  11278665    
202114 PI3K Class IA family   pathway input plasma membrane active   
202100 TRAIL  TRAILR1   modification input integral to membrane 11376335    
202102 Caspase 8   modification input 9311998  10894160  11376335  16940186  15105837  10894161  10783243    
202105 TRAIL  TRAILR1  FADD   modification input integral to membrane 9430227  16940186  10958661    
202110 RIP   modification input 10521396  11461927    
202129 ceramide   cell death agent 16636669    
202127 sphingomyelin   modification input 11031259  1313189  16636669    
202119 MKK4   modification input cytoplasm 9891069  10521444    
202104 Caspase 10 (cleaved)   pathway input active   
202096 TRAIL  TRAILR2   modification input integral to membrane 10894160  10894161  10783243