Related Signaling interaction pathway:

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CD40/CD40L signaling

Related component ;click for the further info from NCBI
NF kappa B1 p50RelAI kappa B alphaC4BPACD40
NF kappa B1BCL-X(L)CD40L (trimer)TRAF3 (trimer)TRAF3
TRAF1TRAF2CBL-bTRAF2 (trimer)MKK4
MEKK1NIKcIAP1cIAP2IL4
JNK family-activeJNK familySTAT5AJAK3 (trimer)TRAF6
TTRAPSTAT5A (dimer)MYCIgMPI3K Class I family
p38alpha-betap38alpha-beta-activeJUNJAK3Zn2+
A20AKT1

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
201395 NF kappa B1 p50  RelA  I kappa B alpha   modification input cytoplasm 12818164    
201397 NF kappa B1  RelA   transcription agent nucleus active 12818164  12354380    
201386 CD40  CD40L (trimer)  TRAF3 (trimer)   pathway input integral to membrane 12122011  11714736    
201370 I kappa B alpha   proteasomal ubiquitin-dependent protein catabolic process input cytoplasm inactive 16260598    
201363 TRAF3   proteasomal ubiquitin-dependent protein catabolic process input inactive 12958312  18997792  11304555  16622006    
201362 TRAF2  CBL-b   proteasomal ubiquitin-dependent protein catabolic process input 11909853  11304555  12370254  17878343    
201379 MKK4   modification input 17143273    
201350 CD40  CD40L (trimer)  TRAF2 (trimer)   regulation of germinal center formation agent integral to membrane 12133933  12354380    
201384 NIK   modification input cytoplasm active 18997792  18997794    
201351 IL4   regulation of isotype switching to IgE isotypes agent extracellular region 12133933  12354380    
201356 JNK family-active   modification input active 14981114    
201385 NIK   degradation input inactive 18997792  18997794    
201349 CD40  CD40L (trimer)   modification input integral to membrane 9718306  10433725  10748139  7544915  10318845    
201391 STAT5A   modification input cytoplasm 10395671    
201366 CD40  CD40L (trimer)   modification input integral to membrane 9718306  8910514  10318845    
201360 CD40  CD40L (trimer)  TRAF6   plasma cell differentiation agent integral to membrane 11967542    
201380 CD40  CD40L (trimer)  TRAF2 (trimer)   modification input membrane raft 18997792    
201381 TRAF3   modification input 18997792  11304555  10748139    
201371 NF kappa B1  RelA   translocation input cytoplasm active 12354380  16260598    
201355 JNK family   modification input 10748139  12133933  12354380  17143273    
201378 CD40  CD40L (trimer)  TRAF2 (trimer)   modification input membrane raft 17143273    
200961 NIK   pathway input cytoplasm active 18997792  18997794    
201348 CD40  CD40L (trimer)   modification input integral to membrane 9718306  10433725  7533327  7527023  10318845    
201394 C4BPA   modification input extracellular region 12818164    
201372 NF kappa B1 p50  RelA  I kappa B alpha   modification input cytoplasm 12958312  10764746  16622006  10318845    
201392 STAT5A   modification input cytoplasm 10395671    
201352 IL4   regulation of isotype switching to IgG isotypes agent extracellular region 12133933  12354380  17143273    
201398 NF kappa B1  RelA   transcription agent nucleus active 12818164  12354380    
201353 IgM   B cell proliferation agent 12133933  12354380  17143273    
201368 NF kappa B1 p50  RelA  I kappa B alpha   modification input cytoplasm 10764746  16260598    
201375 CD40  CD40L (trimer)  TRAF6   modification input integral to membrane 11406619    
201383 TRAF3   modification input 18997792  18997794    
201367 CD40  CD40L (trimer)  TRAF2 (trimer)   modification input integral to membrane 16260598    
201354 p38alpha-beta   modification input 12133933  12354380  17143273    
201369 NF kappa B1 p50  RelA  I kappa B alpha   modification input cytoplasm 16260598    
201357 JUN   modification input nucleus 17143273    
201359 CD40  CD40L (trimer)  TRAF6   B cell affinity maturation agent integral to membrane 11967542    
201347 CD40L (trimer)   modification input integral to membrane 1385114  1374165    
201374 JNK family   modification input 17878362  10318845  16260598    
201382 cIAP1  cIAP2   modification input 18997794    
201389 CD40  CD40L (trimer)   modification input integral to membrane 9718306  10433725  10748139  7544915  17878343  10318845    
201373 p38alpha-beta   modification input 10318845  16260598    
201390 CD40L (trimer)   modification input integral to membrane 1385114  9133417  1374165  10395671    
201364 CD40  CD40L (trimer)  TRAF2 (trimer)   modification input integral to membrane 7544915    
201399 CD40  CD40L (trimer)   modification input integral to membrane 10764746    
201393 STAT5A (dimer)   translocation input cytoplasm 10395671    
201388 NF kappa B1  RelA   pathway input nucleus active 16260598    
201358 CD40  CD40L (trimer)  TRAF2 (trimer)   translocation input integral to membrane 10748139    
201396 NF kappa B1  RelA   transcription agent nucleus active 12818164  12354380    
201376 AKT1   modification input cytoplasm 11406619  16260598