Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



Insulin Pathway

Related component ;click for the further info from NCBI
HRASGDPInsulin ReceptorInsuliIRS1
GRB2SHCSosSHIPGTP
FOXO3ASGK1Par3Par6TC10
CIP4PI-3KInsulinIRS3CBL
APSCAPCrk-IIC3Gp62DOK
RasGAPShcp70S6KPI-3-4-5-P3PI-3-4-P2
Caveolin-1Atypical PKCs4E-BP1AKT1PTP1B
SOS1GRB14PDK1cAMPCRK-II
NCK1H2O2Na+ENaCExocyst
GRB10Sos1AKT2PI-4-5-P2LRP
NCK2SHP2Shp2APS homodimer

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
200582 HRAS  GDP   modification input inactive 10499514  8144662  8114695  8196603  15486046    
200641 FOXO3A   modification input cytoplasm active 11154281    
200632 Par3  Par6   translocation input 14734537    
200592 PI-3K   pathway input plasma membrane active   
200580 Insulin Receptor  Insulin  IRS1   modification input 10499514  8491186  8449939  7685165  15486046  9083103  8316835    
200591 PI-3K   modification input plasma membrane 10329736    
200625 CBL  APS  CAP  Crk-II   modification input 8524328    
200596 p62DOK  RasGAP   negative regulation of MAPKKK cascade agent   
200606 Insulin Receptor  Insulin   subnet input   
200635 Insulin Receptor  Insuli  IRS1  GRB2  Shc   modification input   
200618 PI-3-4-5-P3   modification input plasma membrane 10499514  9891043  9111325    
200640 SGK1   translocation input active   
200630 Caveolin-1   modification input 12036959    
200626 TC10  GDP   modification input 11502760  11309621  11821390    
200633 Atypical PKCs   translocation input active 14734537    
200613 4E-BP1   modification input 10330191    
200598 Insulin Receptor  Insulin   modification input 1321126  8244979  1599438    
200627 TC10  GTP   modification input membrane raft active 12242347    
200581 Insulin Receptor  Insuli  IRS1  GRB2  SHC   modification input 8114695    
200576 Insulin   modification input extracellular region   
200637 SGK1   modification input 11096081    
200624 CBL  APS  CAP   modification input 11997497  8524328    
200609 Insulin Receptor  Insulin  GRB14  PDK1   modification input 12147684    
200612 p70S6K   modification input cytoplasm 10330191    
200595 p62DOK   modification input 11551902    
200577 Insulin Receptor  Insulin   modification input 8626723  9083103  11287630  7983051    
200605 PTP1B   modification input plasma membrane 15192089  11297536    
200639 Na+   translocation input 11832334    
200642 FOXO3A   modification input cytoplasm active 11154281    
200629 TC10  GTP  CIP4  Exocyst   subnet input membrane raft active   
200594 p62DOK   modification input 11551902    
200628 TC10  GTP  CIP4   modification input membrane raft active 12687004    
200611 AKT2   modification input cytoplasm 9065430  9109420  8978681  8524413  12147684    
200614 Atypical PKCs   modification input 9348199  8999972  15787604    
200607 PI-4-5-P2   modification input plasma membrane 11438544    
200602 Insulin Receptor  Insuli  IRS1  GRB2  SHC  PTP1B   modification input 1321126  8244979  1599438    
200590 Insulin Receptor  Insulin   modification input 10329736    
200601 Insulin Receptor  Insuli  IRS1  GRB2  SHC   modification input 8999839  8826975  10807907  10660596    
200584 HRAS  GDP   modification input inactive 7806540  8144662  8114695  11551902  7983051    
200622 Insulin Receptor  Insulin  IRS1   translocation input 11121405  10544179    
200578 PI-3K   modification input plasma membrane 8383963  8385105  1381348  1375946    
200599 Insulin Receptor  Insulin   modification input 1321126  8244979  1599438    
200600 Insulin Receptor  Insulin   transcription agent 8244979    
200616 SHIP   modification input 10499514    
200587 Insulin Receptor  Insulin  IRS1   modification input 8265614  11171109    
200610 AKT1   modification input cytoplasm 9065430  9109420  8978681  8524413  12147684    
200608 PDK1   modification input cytoplasm 15210700    
200593 Insulin Receptor  Insulin  SHC   modification input 8798417  9369444    
200638 ENaC   modification input 11832334    
200589 Insulin Receptor  Insulin  IRS1   modification input 7629070    
200615 Atypical PKCs   subnet input membrane raft active 2123524  7581368    
200604 Insulin Receptor  Insuli  IRS1  GRB2  SHC  Sos   modification agent 11297536    
200583 Insulin Receptor  Insulin  SHC   modification input   
200623 CBL   modification input cytoplasm 11001060  9447983  11997497  14690593