Related Signaling interaction pathway:

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LPA receptor mediated events

Related component ;click for the further info from NCBI
PLDLPALPA1-2-3alpha 1b-AdrenoceptorPKC (alpha
betaepsilonzeta)HB-EGFEGFR
IL8PaxillinTiam1PI3K-betaPKC epsilon
MAGI-3LPA2RhoALPA3HRAS
GTPArachidonic acidNF kappa B1 p50RelAAdenylyl Cyclase
cAMPLPA4Ca2+IP3Gab1
GDPGNB1GNG2Gi familyTRIP6
SrcTauMMP2I kappa B alphaPKC delta
p130 CasFAK1CRKPYK2RAFTK
HB-EGF (63-148)AP1LPA1PKDRAC1
Rac1Gq familyG12G13Ca ++
PLCgamma1LYNGsk3betaGi(betagamma)
RhoGEF1H2O2DAGNHERF2MMP9
Pro-Caspase 3Caspase 3 (cleaved)IL6PI-4-5-P2PIP3
PLC beta3AKT1

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
200562 PLD   modification input 1637305  10420989  11243883    
200547 alpha 1b-Adrenoceptor   modification input 10779388  12880866    
200557 HB-EGF  EGFR   transcription agent active 16197369  16289596  16687414    
200523 Paxillin   stress fiber formation agent cytoplasm active 7510708  7527052    
200500 Tiam1   modification input 9407095    
200574 MAGI-3   modification input 16904289    
200575 RhoA   modification input 16904289    
200542 LPA   modification input   
200512 HRAS  GTP   arachidonic acid secretion agent active 2551506  11040035    
200541 NF kappa B1 p50  RelA   pathway input nucleus active   
200540 NF kappa B1 p50  RelA   transcription agent nucleus active 15728708  15461590    
200520 Adenylyl Cyclase   cAMP biosynthetic process inhibitor inactive   
200539 NF kappa B1 p50  RelA   translocation input cytoplasm active   
200494 LPA4   subnet input   
200251 Ca2+   translocation input calcium store 3919143  15879121  17675482  9820480  19158393  9722546  12598525  17242406  9398617  12482967  9115251  9435453  8125934    
200548 EGFR   modification input transmembrane 10551845    
200509 HRAS  GDP   modification input inactive 7809106    
200563 TRIP6   modification input 15988003  14688263    
200528 Tau   positive regulation of microtubule depolymerization agent active 10601262  16452634    
200535 MMP2   endothelial cell migration agent 15461590  15878967    
200538 NF kappa B1 p50  RelA  I kappa B alpha   modification input cytoplasm 15280372    
200564 TRIP6   modification input 15988003  14688263    
200545 Paxillin   modification input cytoplasm 16199135    
200508 RhoA   contractile ring contraction involved in cytokinesis agent active 9600933    
200556 EGFR   modification input transmembrane 16687414    
200532 AP1   transcription agent nucleus active 16197369    
200525 PYK2  RAFTK   modification input cytoplasm 16452634    
200521 Paxillin   modification input cytoplasm 10807867  7510708  7527052  7561682    
200559 PKD   modification input 10644509    
200501 RAC1  GDP   modification input inactive 12393875    
200531 AP1   modification input nucleus 16197369    
200514 Gq family   modification input   
200505 G12  G13   modification input cytoplasm 9600933    
200543 LPA   modification input   
200544 PYK2  RAFTK   modification input cytoplasm 16199135    
200515 PLCgamma1   modification input cytoplasm   
200553 LYN   modification input cytoplasm 16687414    
200503 Rac1  GTP   lamellipodium assembly agent active 12973357  12589802  11886862  12393875  18033240  15793570  15351743    
200526 Gsk3beta   modification input cytoplasm 10601262  16452634    
200497 Gi(beta  gamma)   modification input cytoplasm active 9600933    
200498 PI3K-beta   modification input plasma membrane 10506190  12393875  9305878  9819398  8647803    
200519 Adenylyl Cyclase   modification input 2551506  7476905  11040035    
200506 RhoGEF1   modification input 9600933    
200511 HRAS  GTP   positive regulation of mitosis agent active 2551506    
200561 H2O2   regulation of stress fiber formation agent 10420989  8805276    
200518 PKC (alpha  beta  epsilon  zeta)   modification input cytoplasm 10342794    
200507 RhoA   modification input 9600933  12393875    
200571 LPA  LPA2   modification input 15728708  15143197    
200502 Rac1  GTP   cell migration agent active 12393875    
200496 LPA   modification input   
200555 HB-EGF   modification input transmembrane 16687414    
200567 Pro-Caspase 3   modification input   
200565 TRIP6  p130 Cas  FAK1  Paxillin   cell migration agent 15988003  14688263    
200566 Pro-Caspase 3   modification input 16890224    
200569 LPA  LPA1-2-3   positive regulation of dendritic cell cytokine production agent 16769764    
200513 Gq family   modification input   
200504 PI3K-beta   modification input plasma membrane 12181443    
200516 PI-4-5-P2   modification input 12482967  16452634    
200537 IL8   translocation input cytoplasm   
200495 LPA   modification input 11948806    
200560 PLD   modification input active 10420989    
200549 PI-4-5-P2   modification input plasma membrane 10551845    
200510 HRAS  GTP   MAPKKK cascade agent active 9405464  12087092  7809106    
200536 PKC delta   modification input cytoplasm   
200573 PI-4-5-P2   modification input 15143197    
200546 Paxillin   cell migration input cytoplasm active 16199135    
200522 FAK1   modification input cytoplasm 7510708  7527052    
200527 Tau   modification input 10601262  16452634    
200499 AKT1   modification input cytoplasm 15928312  10766839  12181443    
200572 PLC beta3   modification input 15143197    
200568 Caspase 3 (cleaved)   apoptosis agent active 10818449    
200534 LPA  LPA1   transcription agent 15878967