Related Signaling interaction pathway:

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ErbB4 signaling events

Related component ;click for the further info from NCBI
ErbB4neuregulin 1 betaErbB4 m80WWP1E4ICDs
ETO2ErbB4 JM-BSTAT5ASTAT5A (dimer)ErbB2
neuregulin 3epiregulinLRIG1gamma secretaseSTAT5B
STAT5B (dimer) activeTAB2NCoR1NEDD4HBEGF
Prolactin receptorProlactinJAK2PI3K Class IA familyGRB2
SHCPSD95ErbB4 CYT2TACEErbB4 ectodomain
ErbB4 CYT2 m80E4ICDs CYT2ITCHYAP1WWOX
neuregulin 2 betaneuregulin 4ERK1-2ERK1-2-activeYAP65
betacellulinGRIN2BFynMDM2

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
200395 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   translocation input integral to membrane 18334649    
200419 ErbB4 m80   modification input integral to membrane active 19047365    
200406 E4ICDs   modification input nucleus active 16815842    
200410 ErbB4   modification input integral to membrane 18721752    
200400 ErbB4 JM-B  ErbB4 JM-B  neuregulin 1 beta  neuregulin 1 beta   translocation input early endosome 18334649    
200386 STAT5A   modification input 15863494    
200408 ErbB4  ErbB2  neuregulin 1 beta   neural crest cell migration agent integral to membrane 12824469  12716924    
200364 ErbB4  ErbB4  neuregulin 3  neuregulin 3   apoptosis inhibitor integral to membrane 12466964    
200436 ErbB4  ErbB2  epiregulin   apoptosis inhibitor integral to membrane 9556621    
200424 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 15282549  15345710    
200401 ErbB4 JM-B  ErbB4 JM-B  neuregulin 1 beta  neuregulin 1 beta   degradation input lysosome 18334649    
200383 ErbB4 m80   modification input integral to membrane active 12454007  11679632  15746097    
200411 STAT5B   modification input cytoplasm 10358079    
200434 E4ICDs  TAB2  NCoR1   glial cell differentiation inhibitor nucleus 17018285    
200433 E4ICDs  TAB2  NCoR1   translocation input cytoplasm 17018285    
200422 E4ICDs   modification input cytoplasm active 19193720    
200378 STAT5A   modification input 18653779    
200366 PI3K Class IA family   modification input 8617750  10722704  18819924  10353604    
200432 E4ICDs   modification input cytoplasm active 17018285    
200405 E4ICDs   translocation input cytoplasm active 16815842    
200373 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta  GRB2  SHC   modification input integral to membrane 17646177  12716924  10725395  10839362    
200362 ErbB4  ErbB2  neuregulin 1 beta   cell proliferation agent integral to membrane 9618494    
200396 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   translocation input early endosome 18334649    
200418 E4ICDs   transcription agent nucleus active 19047365    
200382 ErbB4 CYT2  ErbB4 CYT2  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 17486069    
200423 E4ICDs   proteasomal ubiquitin-dependent protein catabolic process input cytoplasm active 19193720    
200385 STAT5A   modification input 10508857  15863494    
200426 E4ICDs CYT2   translocation input cytoplasm active 16815842  15985438    
200388 STAT5A (dimer)   translocation input cytoplasm active 15534001  15746097    
200398 ErbB4 JM-B  ErbB4 JM-B  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 18334649    
200402 YAP1   translocation input cytoplasm 12807903    
200367 PI3K Class IA family   modification input 8617750  10867024    
200363 ErbB4  ErbB2  neuregulin 4   cell proliferation agent integral to membrane 10867024  10348342    
200377 ErbB4  ErbB4  HBEGF  HBEGF   modification input integral to membrane 18653779    
200389 STAT5A (dimer)   translocation input cytoplasm active 17486069    
200397 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   degradation input lysosome 17463226  19047365  18334649    
200429 E4ICDs   translocation input cytoplasm active 19193720    
200430 E4ICDs   degradation input lysosome active 19193720    
200391 STAT5A (dimer)   epithelial cell differentiation agent nucleus active 18653779  12824469  12954715    
200399 ErbB4 JM-B  ErbB4 JM-B  neuregulin 1 beta  neuregulin 1 beta   translocation input integral to membrane 18334649    
200374 ERK1-2   modification input 10693928  12716924    
200357 ErbB4  ErbB2  HBEGF   cell proliferation agent integral to membrane 9618494    
200379 STAT5A (dimer)   translocation input cytoplasm active 18653779  15863494    
200369 PI3K Class IA family   apoptosis inhibitor plasma membrane active 17085783  10722704  9618494  8702723  11731109    
200390 STAT5A (dimer)   epithelial cell differentiation agent nucleus active 7559778  16837552  12824469  12954715  10508857  15534001  9663464  15746097    
200404 YAP65   translocation input cytoplasm 15023535    
200392 E4ICDs   modification input cytoplasm active 17463226  9362517    
200381 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 9685416  10744726    
200394 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 18334649    
200371 PI3K Class IA family   dendrite morphogenesis agent plasma membrane active 18819924    
200372 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 10722704  7759543  10867024  18721752  15985438    
200368 PI3K Class IA family   modification input 9135143    
200360 ErbB4  ErbB2  betacellulin   cell proliferation agent integral to membrane 9618494  10867024    
200409 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   axon guidance agent integral to membrane 7477376    
200358 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   cell proliferation agent integral to membrane 10722704  9618494    
200416 GRIN2B   modification input 17460065    
200412 STAT5B (dimer) active   translocation input cytoplasm active 10358079    
200421 ErbB4 m80   proteasomal ubiquitin-dependent protein catabolic process input integral to membrane active 19047365    
200370 PI3K Class IA family   chemotaxis agent plasma membrane active 10722704  10353604  9135143    
200361 ErbB4  ErbB4  betacellulin  betacellulin   cell proliferation agent integral to membrane 9618494    
200420 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 19047365    
200365 PI3K Class IA family   modification input 8617750  10867024  10353604    
200375 ERK1-2-active   neuron projection morphogenesis agent active 10693928    
200380 ErbB4  ErbB2  neuregulin 1 beta   modification input integral to membrane 9685416  10744726  15746097    
200425 MDM2   modification input nucleus 15985438    
200407 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   heart development agent integral to membrane 12824469  7477376    
200403 E4ICDs   modification input cytoplasm active 16061658    
200415 ErbB4  ErbB4  neuregulin 1 beta  neuregulin 1 beta   modification input integral to membrane 18819924  17460065    
200359 ErbB4 CYT2  ErbB4 CYT2  neuregulin 1 beta  neuregulin 1 beta   cell proliferation agent integral to membrane 10722704  9618494    
200384 ErbB4 CYT2 m80   modification input integral to membrane active 17486069