Related Signaling interaction pathway:

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Endothelins

Related component ;click for the further info from NCBI
ETA receptorEndothelin-1CysLT1Adenylyl CyclaseERK1-2
MEK1-2-activeERK1-2-activeCa ++JNK1p130Cas
CRKSrcPYK2MEK1-2RAF1
ETB receptorGqGTPPLC betaCysLT2
HRASFOSCOL1A2GDPTypical PKCs
Rho family GTPaseG12Rho family GTPase-activeCa2+ETB
ET3Endothelin-3PI-4-5-P2DAGIP3
MMP1Gs familyGsET2Endothelin-2
Gq familyETARAC1Rac1cPLA2-alpha
Arachidonic acidET1Gip38 alphaNHE1
COL3A1K +AKT1TRPC6JAK2
c-JunGaiNHE3

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
200202 ETA receptor  Endothelin-1   transcription agent integral to membrane 17627891    
200219 Adenylyl Cyclase   cAMP biosynthetic process agent active 1319997    
200176 ERK1-2   modification input 17272394  17569879  15466214    
200217 Ca ++   translocation input extracellular region 1905483  11078350  2558572    
200238 JNK1   modification input 12719447    
200175 MEK1-2   modification input cytoplasm   
200214 ETB receptor  Endothelin-1  Gq  GTP   modification input integral to membrane active 1319997    
200203 ETA receptor  Endothelin-1   transcription agent integral to membrane 17627891    
200174 RAF1   modification input 17569879    
200232 ERK1-2-active   transcription agent active 9595433    
200197 ETA receptor  Endothelin-1   transcription agent integral to membrane 11231316    
200173 HRAS  GDP   modification input inactive 17569879  12606754    
200177 Rho family GTPase   modification input 10364236  17533154    
200182 Ca2+   pathway input cytoplasm active2 17533154    
200169 ETB   modification input transmembrane 2545198    
200216 PI-4-5-P2   modification input 1319997  2558572  3144974    
200199 ETA receptor  Endothelin-1   transcription inhibitor integral to membrane 11231316    
200208 ETA receptor  Endothelin-1   modification input integral to membrane 1319997    
200167 ETB   modification input transmembrane 2545198    
200210 ETA receptor  Endothelin-1   modification input integral to membrane 1319997    
200213 ETA receptor  Endothelin-1  Gq  GTP   modification input integral to membrane active 1319997    
200168 ETA   modification input transmembrane 2545198    
200221 Ca ++   translocation input calcium store 1905483    
200237 p130Cas   modification input 12719447    
200209 ETA receptor  Endothelin-1   modification input integral to membrane 10364236    
200225 ETA receptor  Endothelin-1   subnet input integral to membrane   
200194 RAC1  GDP   modification input inactive 15047866    
200236 cPLA2-alpha   arachidonic acid secretion agent active 12922939  8843717    
200165 ETB   modification input transmembrane 17535295  2545198    
200220 ETB receptor  Endothelin-1  Gi  GTP   cAMP biosynthetic process inhibitor integral to membrane active 1319997    
200222 Typical PKCs   translocation input cytoplasm 8319594    
200185 p38 alpha   modification input 8940174    
200241 NHE1   modification input 12397581    
200166 ETA   modification input transmembrane 2545198    
200195 Rac1  GTP   positive regulation of muscle contraction agent active 15047866    
200164 ETA   modification input transmembrane 2545198    
200215 PI-4-5-P2   modification input 1319997  2558572  3144974    
200198 ETA receptor  Endothelin-1   transcription agent integral to membrane 11231316    
200179 JNK1   modification input 12606754    
200235 cPLA2-alpha   modification input 12922939  8764613    
200193 AKT1   positive regulation of muscle contraction agent plasma membrane active 15047866    
200196 ETB receptor  Endothelin-1   transcription agent integral to membrane 11231316    
200234 ERK1-2-active   regulation of vascular smooth muscle contraction agent active 15200122    
200180 JNK1   transcription agent active 17533154    
200181 Ca2+   translocation input calcium store 17533154    
200192 AKT1   modification input plasma membrane 15047866    
200190 JAK2   modification input cytoplasm 17526654    
200239 JNK1   transcription agent active 12719447    
200211 ETB receptor  Endothelin-1   modification input integral to membrane 1319997    
200212 ETB receptor  Endothelin-1   modification input integral to membrane 1319997    
200218 Adenylyl Cyclase   modification input 1319997    
200178 JNK1   modification input 17569879  12606754  17533154    
200242 NHE3   modification input 8617878