Related Signaling interaction pathway:

Data buffering takes about 1 or more minute acording to the network size.



TGF-beta receptor signaling

Related component ;click for the further info from NCBI
EIF2A14-3-3 ETGFBTGFBR2TGFBR1
SMAD7GADD34SMAD2-3DAB2SMAD2-3-active
AxinARKADIADAXXXIAPTAK1
TAB familySTRAPPMLSARAAP2B2
PDK1SMAD2YAP65NEDD4-2WWP1
betaglycanTGFBR1 (dimer)Par6occludinbetaglycan (dimer)
SMAD3Axin1SnoNSMURF2ITCH
TRAP-1SMAD4ELFPPP2R2ATGFB family (dimer)
TGFBR2 (dimer)CTGFkm23-1ENDOFINDAPPER2
beta cateninRhoASMURF1CAMKIIASMURF1-2
Caveolin-1FKBP12CAV1p70S6KPPP2CB
PPP2CASHCGRB2SOS1Grb2
beta Arrestin2km23-1 (dimer)PPP1CABAMBI

Related interaction Related unit Interaction type Unit type Subcellular localization Activity state Related Article
207708 EIF2A   modification input 11781097    
207688 TGFB  TGFBR2  TGFBR1   modification input integral to membrane active 14718519    
207694 SMAD2-3   modification input 11387212    
207673 Axin  ARKADIA   modification input cytoplasm 14657019  16601693    
207700 TGFB  TGFBR2  TGFBR1  DAXX   JNK cascade agent integral to membrane active 11483955    
207704 XIAP   modification input 12589052  17384642  8533096  16157589    
207675 TGFB  TGFBR2  TGFBR1  PML  SARA  SMAD2-3  AP2B2   modification input early endosome active 9865696    
207710 TGFB  TGFBR2  TGFBR1  STRAP   modification input integral to membrane active 16251192  17327236    
207677 SMAD2   modification input cytoplasm 9335507  9865696  9346908  11739411  10934479  10757800    
207671 TGFB  TGFBR2  TGFBR1   modification input integral to membrane active 12118366    
207691 TGFB  TGFBR2  TGFBR1  STRAP  SMAD7  NEDD4-2   proteasomal ubiquitin-dependent protein catabolic process input integral to membrane 15496141    
207720 TGFB  TGFBR2  TGFBR1   modification input integral to membrane active 15221015    
207685 TGFB  TGFBR2  betaglycan   modification input integral to membrane active 15761148    
207693 SMAD2  NEDD4-2   proteasomal ubiquitin-dependent protein catabolic process input 15496141    
207705 TAK1  XIAP   proteasomal ubiquitin-dependent protein catabolic process input 16157589    
207672 Axin  SMAD3   modification input 11438668    
207703 SnoN   proteasomal ubiquitin-dependent protein catabolic process input 11389444    
207722 SMAD7   proteasomal ubiquitin-dependent protein catabolic process input 15946939    
207681 TRAP-1  SMAD4   subnet input   
207697 ELF   modification input 12543979    
207698 TGFB  TGFBR2  TGFBR1   modification input integral to membrane active 9774674    
207665 TGFB family (dimer)   modification input extracellular region active 1657407  9155023  1310899  2879635  9169454  8391934  12134160  1333888  7693660    
207674 Axin  ARKADIA  SMAD7   proteasomal ubiquitin-dependent protein catabolic process input cytoplasm 14657019  16601693    
207717 TGFB  TGFBR2  TGFBR1  km23-1  SMAD2   modification input early endosome active 17420258    
207706 TAK1  TAB family   JNK cascade agent active 16157589    
207709 TGFB  TGFBR2  TGFBR1  ENDOFIN  SMAD4   modification input integral to membrane active 17272273    
207725 TGFB  TGFBR2  TGFBR1   degradation input integral to membrane active 17197390    
207668 TGFB  TGFBR2  TGFBR1  STRAP   modification input integral to membrane active 9335507  9215638  11739411  10757800  9856985    
207679 SMAD2   subnet input cytoplasm active   
207702 SMAD2   modification input cytoplasm active 11389444  12475967  11016919    
207723 beta catenin   translocation input cytoplasm 15684397    
207687 RhoA   proteasomal ubiquitin-dependent protein catabolic process input 15761148    
207711 SMAD2   modification input cytoplasm active 11027280    
207692 SMAD2   modification input cytoplasm active 15496141    
207669 TGFB  TGFBR2  TGFBR1   modification input integral to membrane active 11583628  12151385  12429842  15356634  9463378  9346908  12717440  9335507  9679059  10777621  9865696  9215638  11163210  12034739  11278251  12356868  10615055    
207707 EIF2A   modification input 11781097    
207690 TGFB  TGFBR2  TGFBR1  STRAP  SMAD7   modification input integral to membrane active 15496141    
207678 SMAD3   modification input cytoplasm 9335507  9865696  11739411  10757800  17327236    
207721 TGFB  TGFBR2  TGFBR1  WWP1  SMAD7   proteasomal ubiquitin-dependent protein catabolic process input integral to membrane 15221015    
207699 p70S6K   modification input active 11124802    
207676 SMAD2-3-active   modification input active 9346908  8893010    
207719 SHC   modification input active 17673906    
205023 TAK1  TAB family   pathway input active 12110587  10748100  11714695    
207667 betaglycan (dimer)   modification input integral to membrane 12958365    
207686 TGFB  TGFBR2  TGFBR1  Par6  occludin   modification input tight junction active 15761148    
207695 TGFB  TGFBR2  betaglycan   modification input integral to membrane active 11278302    
207701 TGFB  TGFBR2  TGFBR1   modification input integral to membrane active 12475967    
207689 TGFB  TGFBR2  TGFBR1  SMAD7  GADD34   modification input integral to membrane active 12134149  14718519    
207680 SMAD3   subnet input cytoplasm active   
207670 TGFB  TGFBR2  TGFBR1  SMAD7  SMURF1-2  CAV1   proteasomal ubiquitin-dependent protein catabolic process input membrane raft 12151385  11163210  11278251  12717440    
207666 FKBP12  TGFBR1 (dimer)   modification input integral to membrane inactive 8756725  8947046  7988555  8047140  7774578  8391934  8576253  9233797  8242743  12958365  1333888  10519551    
207696 TRAP-1   modification input 11278302    
207724 SHC  Grb2  SOS1   MAPKKK cascade agent active 7706248  8798398  17673906  1544886    
207718 SHC   modification input 17673906